Evidence map›Paper›PMID 42585320›Full record

ArticleScience advances2026

Direct bacterial transcript visualization illuminates spatiotemporal environmental adaptation of

Anna-Lisa E Lawrence, Shumin Tan

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Anna-Lisa E LawrenceDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.ORCID 0000-0002-2865-0238
Shumin TanDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.ORCID 0000-0003-1093-2576

Funding

Mycobacterium tuberculosis environmental signal integration: single cell in vivo understanding of its influence on infection heterogeneity and treatment efficacyR01AI143768 · NIAID · TUFTS UNIVERSITY BOSTON · PI TAN, SHUMIN · 2019 to 2023
$3.0M
Elucidating spatio-temporal innate immune cell modulation of Mycobacterium tuberculosis stress response and replication heterogeneityF32AI188687 · NIAID · TUFTS UNIVERSITY BOSTON · PI Anna-Lisa Edith Lawrence · 2025 to 2026
$160k
NIAID NIH HHS F32 AI188687NIAID NIH HHS R01 AI143768
6 · The paper itself

Abstract

Spatiotemporal environmental variation results in marked heterogeneity in bacterial infection progression and disease outcome, with vital consequences for treatment success. For the globally important pathogen

Indexed as

Adaptation, PhysiologicalLungMycobacterium tuberculosisRNA, BacterialRNA, MessengerBacterial ProteinsGene Expression Regulation, BacterialHost-Pathogen InteractionsHumansIn Situ Hybridization, FluorescenceLipid MetabolismBacterial ProteinsRNA, BacterialRNA, Messenger

Identifiers

PMID42585320
PMCPMC13464648

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.