Evidence map›Paper›PMID 42585316›Full record

ArticleScience advances2026

Prediction of mild cognitive impairment progression using time-sensitive multimodal biomarkers.

Jonathan Gallego-Rudolf, Alex I Wiesman, Yara Yakoub, Henrik Zetterberg, Kaj Blennow, Sylvain Baillet, Sylvia Villeneuve, PREVENT-AD Research Group

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jonathan Gallego-RudolfDouglas Research Centre, McGill University, Montreal, Canada.ORCID 0000-0002-1048-2352
Alex I WiesmanMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada.ORCID 0000-0003-0917-1570
Yara YakoubDouglas Research Centre, McGill University, Montreal, Canada.ORCID 0000-0002-4769-7162
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0003-3930-4354
Kaj BlennowInstitute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.ORCID 0000-0002-1890-4193
Sylvain BailletMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada.ORCID 0000-0002-6762-5713
Sylvia VilleneuveDouglas Research Centre, McGill University, Montreal, Canada.ORCID 0000-0003-2338-0467
PREVENT-AD Research Group

Funding

BrainStorm: Highly Extensible Software for Advanced Electrophysiology and MEG/EEG ImagingR01EB026299 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LEAHY, RICHARD M · 2018 to 2025
$5.4M
Investigating the impact of loneliness on brain aging and pre-symptomatic Alzheimer's disease progressionR01AG068563 · NIA · MCGILL UNIVERSITY · PI BZDOK, DANILO, SPRENG, ROBERT NATHAN · 2020 to 2024
$2.3M
Characterizing the interaction between neural attention and somato-motor systems in non-demented patients with Parkinson's diseaseF32NS119375 · NINDS · MCGILL UNIVERSITY · PI WIESMAN, ALEX I · 2020 to 2023
$205k
NIA NIH HHS R01 AG068563NIBIB NIH HHS R01 EB026299NINDS NIH HHS F32 NS119375
6 · The paper itself

Abstract

Alzheimer's disease (AD) develops silently for years before symptoms emerge, making early identification of at-risk individuals essential for prevention trials and early intervention. We tested whether combining neurophysiological, imaging, and blood biomarkers improves prediction of progression to mild cognitive impairment (MCI) in cognitively unimpaired older adults with a family history of AD (

Indexed as

BiomarkersCognitive DysfunctionAgedAlzheimer DiseaseDisease ProgressionFemaleHumansMagnetic Resonance ImagingMagnetoencephalographyMalePositron-Emission Tomographytau ProteinsBiomarkerstau Proteins

Identifiers

PMID42585316
PMCPMC13464481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.