ArticleScience advances2026
Interfacial amplifier: High-throughput visual protein detection via droplet dynamics.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Rapid, visual protein detection at ultralow cost remains a critical unmet need for scalable point-of-care testing. We introduce a high-throughput platform leveraging interfacial droplet dynamics on a slippery liquid-infused porous surface (SLIPS) to directly translate protein-specific adsorption into macroscopic behavior. Protein concentration and identity modulate the critical sliding angle of droplets via interfacial film formation, enabling pretreatment-free, instrument-free identification of clinically relevant targets like proteinuria within minutes. This approach achieves parallel analysis of 170 samples on a single A4-sized substrate (5 minutes, ∼$0.008 per sample), requiring only visual readout. By amplifying nanoscale interfacial interactions into intuitive visual outputs, our SLIPS-based technology establishes a scalable, user-friendly paradigm for decentralized diagnostics and continuous health monitoring across diverse settings.
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