Evidence map›Paper›PMID 42585291›Full record

ArticleScience translational medicine2026

Ultrasound-guided renal artery administration of angiopoietin-1 RNA therapy slows the progression of preclinical WT1 glomerular disease.

Saif N Malik, Jennifer C Chandler, Ruhina Maeshima, Maria Kolatsi-Joannou, William J Mason, Lauren G Russell, Shunping Han, Yanis Harfouche, Daniyal J Jafree, Emily A E Moore and 13 more

Abstract read
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Saif N MalikDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0000-0002-8042-3665
Jennifer C ChandlerDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0000-0001-9785-4528
Ruhina MaeshimaGenetics and Genomic Medicine Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0000-0003-1473-9757
Maria Kolatsi-JoannouDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
William J MasonDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0000-0001-6014-3562
Lauren G RussellDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
Shunping HanGenetics and Genomic Medicine Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0000-0002-4640-6116
Yanis HarfoucheDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
Daniyal J JafreeDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0000-0001-8235-0394
Emily A E MooreDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0009-0006-6344-9325
Hanna GautierDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
Christina KatsivaCentre for Advanced Biomedical Imaging, University College London, London WC1E 6DD, UK.
Reem Al-SaadiDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0000-0002-0816-5649
Kathy Pritchard-JonesDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0000-0002-2384-9475
Daniel J StuckeyCentre for Advanced Biomedical Imaging, University College London, London WC1E 6DD, UK.ORCID 0000-0001-8888-627X
Andrew V BenestEndothelial Quiescence Group and Tumour and Vascular Biology Laboratories, Division of Cancer and Stem Cells, Centre for Cancer Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.
David O BatesEndothelial Quiescence Group and Tumour and Vascular Biology Laboratories, Division of Cancer and Stem Cells, Centre for Cancer Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0003-4850-2360
Paul J WinyardDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
Aoife M WatersDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0000-0003-4520-5635
Luigi GnudiUnit for Metabolic Medicine, Section of Vascular Biology and Inflammation, School of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre for Excellence, Faculty of Life Sciences & Medicine, King's College London, London WC2R 2LS, UK.ORCID 0000-0002-6353-630X
Stephen L HartGenetics and Genomic Medicine Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0000-0001-8254-376X
Tammy L KalberCentre for Advanced Biomedical Imaging, University College London, London WC1E 6DD, UK.
David A LongDevelopmental Biology and Cancer Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0000-0001-6580-3435

Funding

Wellcome Trust
6 · The paper itself

Abstract

Mutations in the transcription factor gene

Indexed as

Angiopoietin-1Disease ProgressionKidney DiseasesKidney GlomerulusWT1 ProteinsAnimalsDisease Models, AnimalHumansIntegrin alphaVbeta3MicePodocytesRNA, MessengerUltrasonographyAngiopoietin-1Integrin alphaVbeta3RNA, MessengerWT1 Proteins

Identifiers

PMID42585291
PMCPMC7619540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.