Evidence map›Paper›PMID 42585248›Full record

ArticlePLoS computational biology2026

Evaluation of short-term multi-target respiratory forecasts over winter 2024-25 in England using sub-ensemble contribution analyses.

Jack Kennedy, William Ferguson, Owen Jones, Steven Riley, Thomas Ward, Maria L Tang, Jonathon Mellor

Abstract read
In one paragraph

Article in PLoS computational biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jack KennedyUK Health Security Agency, London, United Kingdom.ORCID 0009-0004-1522-7088
William FergusonUK Health Security Agency, London, United Kingdom.
Owen JonesUK Health Security Agency, London, United Kingdom.ORCID 0000-0002-8410-9585
Steven RileyUK Health Security Agency, London, United Kingdom.
Thomas WardUK Health Security Agency, London, United Kingdom.
Maria L TangUK Health Security Agency, London, United Kingdom.
Jonathon MellorUK Health Security Agency, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpidemic forecasting research often assesses ensembles and their component models using probabilistic scoring rules. Quantifying how individual models affect ensemble performance is challenging, particularly across multiple targets and spatial scales.

methodsWe present Winter 2024-25 forecasts of Influenza and COVID-19 hospital admissions in England and conduct a retrospective simulation using the operational component models. Forecasts were scored using the per capita weighted interval score (pcWIS) for counts and the ranked probability score (RPS) for ordinal trend direction. We compared retrospective forecasts, used generalised additive models (GAMs) to estimate the expected change in score from the inclusion of a model in a sub-ensemble (an ensemble formed from a subset of available models), and used Pareto analysis to understand which sub-ensembles were Pareto-optimal across scoring rules.

resultsNationally, there was a 47% improvement in Influenza pcWIS versus sub-ensembles. However, Influenza operational ensembles were on average 22% worse than sub-ensembles, when measured by RPS. For COVID-19, operational ensembles were 43% and 280% worse on average, than retrospective sub-ensembles by pcWIS and RPS, respectively. However, COVID-19 operational ensembles were on average 2% (pcWIS) and 13% (RPS) better than individual operational models. For influenza, operational ensembles were, on average, 58% (pcWIS) and 41% (RPS) better than individual models. The sub-ensemble simulation showed how individual models influenced the ensemble scores during different epidemic phases. The Pareto analysis demonstrated that there can be a trade-off between relative direction and absolute count score optimisation.

Indexed as

COVID-19Influenza, HumanComputational BiologyComputer SimulationEnglandForecastingHospitalizationHumansModels, StatisticalPandemicsRetrospective StudiesSARS-CoV-2Seasons

Identifiers

PMID42585248
PMCPMC13506087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.