Evidence map›Paper›PMID 42584998›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

TBC1D23-AAVR interaction drives endosome-to-TGN trafficking required for rAAV transduction.

Xiujuan Zhang, Ariful Habib, Shane McFarlin, Donovan Richart, Soo Yeun Park, Fang Cheng, Jinxi Wang, Ziying Yan, Jianming Qiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Xiujuan ZhangDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160.ORCID 0009-0007-4268-4171
Ariful HabibDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160.ORCID 0009-0006-3020-9990
Shane McFarlinDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160.ORCID 0009-0002-1817-7915
Donovan RichartDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160.ORCID 0000-0003-0048-4810
Soo Yeun ParkDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.
Fang ChengDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160.
Jinxi WangDepartment of Orthopedic Surgery and Sports Medicine, University of Kansas Medical Center, Kansas City, KS 66160.
Ziying YanDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0001-8210-5567
Jianming QiuDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160.ORCID 0000-0001-9850-1695

Funding

Viral and Host Determinants of Parvovirus ReplicationR01AI150877 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING · 2020 to 2024
$2.4M
Development of novel approaches for gene editing therapies of cystic fibrosisR01HL174593 · NHLBI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Jianming Qiu, Ziying Yan · 2024 to 2026
$1.9M
Spinning-Disk Confocal Microscope for Wide-Field, Super-Resolution, and Live-Cell ImagingS10OD032207 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SMITH, PETER G · 2022 to 2022
$600k
Development of myotropic human bocavirus vectors for gene therapyR21AI182645 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING, YAN, ZIYING · 2024 to 2025
$441k
Identification of the AAVR-independent AAV entry pathwayR21AI166293 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING · 2021 to 2022
$425k
Studies of the KIAA0319L-mediated productive transduction pathways of rAAV vectorsR21AI180416 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING · 2024 to 2025
$419k
Cystic Fibrosis Foundation (CFF) YAN23G0HHS | NIH (NIH) AI166293HHS | NIH (NIH) AI180416HHS | NIH (NIH) AI182645HHS | NIH (NIH) HL174593NHLBI NIH HHS R01 HL174593NIAID NIH HHS R01 AI150877NIAID NIH HHS R21 AI166293NIAID NIH HHS R21 AI180416NIAID NIH HHS R21 AI182645NIH HHS S10 OD032207
6 · The paper itself

Abstract

The adeno-associated virus receptor (AAVR; also known as KIAA0319L) is the proteinaceous receptor required for the transduction of multiserotype adeno-associated viruses (AAVs). While the extracellular polycystic kidney disease (PKD) domains of AAVR directly bind AAV capsids, the function of its C-terminal cytosolic domain (AAVR-C) in governing AAV internalization and intracellular trafficking remains undefined. Using targeted pulldown of AAVR-interacting host proteins with a glutathione S-Transferase (GST)-fused AAVR-C recombinant protein (GST-AAVR-C) as a bait, we identified that TBC1 domain family member 23 (TBC1D23), a specialized intracellular trafficking adaptor and bridging factor, binds AAVR via the AAVR-C and mediates AAV's endosome-to-

Indexed as

DependovirusEndosomesGTPase-Activating Proteinstrans-Golgi NetworkHEK293 CellsHumansProtein BindingProtein TransportReceptors, Cell SurfaceTransduction, GeneticGTPase-Activating ProteinsKIAA0319L protein, humanReceptors, Cell SurfaceAAVintracellular traffickingreceptortransduction

Identifiers

PMID42584998
PMCPMC13486524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.