Evidence map›Paper›PMID 42584925›Full record

ArticleMicrobiology (Reading, England)2026

Enlarging viral mutation estimation: a view from the distribution of mutation rates.

Taima Naomi Furuyama, Isabel Maria Vicente Guedes de Carvalho, Luiz Mário Ramos Janini, Fernando Antoneli

Abstract read
In one paragraph

Article in Microbiology (Reading, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Taima Naomi FuruyamaLaboratório de Virologia, Instituto Butantan, São Paulo, SP, Brazil.
Isabel Maria Vicente Guedes de CarvalhoLaboratório de Virologia, Instituto Butantan, São Paulo, SP, Brazil.
Luiz Mário Ramos JaniniDepartamento de Microbiologia, Imunologia e Parasitologia, Departamento de Medicina, Laboratório de Retrovirologia, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.
Fernando AntoneliCentro de Bioinformática Médica, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The problem of empirical estimation of mutation rates is fundamental to the understanding of viral evolution. The estimation of viral mutation rates is based on varied and often complex methods carried out through experiments essentially designed to count mutation frequencies. Mutation rates are defined as the probabilities of nucleotide substitutions, typically reported as a single number in units of mutation (substitution) per base (nucleotide) per replication cycle or per cell infection, depending on the replication mode of the virus. Even more, the uncertainty quantification of these estimates is so difficult that it is rare to find it reported in the literature. The values for the same virus reported in literature fall within a broad range, sometimes spanning two orders of magnitude. For instance, the mutation rates range from 10

Indexed as

Mutation RateVirusesEvolution, MolecularModels, GeneticMutationVirus ReplicationBayesian inferenceinformation dimensioninformation theorymutational ratesmutation rate distributionRNA viral populationssingle-round replication cycle

Identifiers

PMID42584925
PMCPMC13465770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.