Generation and Validation of an Acan-Cre Mouse Line to Selectively Label Class-B Excitatory Neurons of the Cerebellar Nuclei.

Julian Cheron, Maggie Lowman, Manjari M-G Anant, Max Siauw, Justus M Kebschull

Abstract read

In one paragraph

Article in Cerebellum (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Julian CheronDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21205, USA.

Maggie LowmanDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21205, USA.

Manjari M-G AnantDepartment of Neuroscience, Johns Hopkins University, Baltimore, MD, 21205, USA.

Max SiauwDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21205, USA.

Justus M KebschullDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21205, USA. kebschull@jhu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cerebellar nuclei form the main output structures of the cerebellum and are composed of a deeply conserved set of cell types. Two excitatory cell classes, Class-A and -B, are present in each cerebellar nucleus and mediate all excitatory output of the cerebellum. To provide genetic access to these cell types, here we identified Acan as a marker gene for Class-B cells and generated a knock-in Acan-P2A-Cre mouse line. We demonstrate that this Acan-Cre line selectively labels Class-B neurons in the cerebellar nuclei and validate its use in viral projection tracing. This new mouse line provides a valuable genetic tool to study cerebellar nuclei organization and function.

Indexed as

Cerebellar NucleiNeuronsAnimalsIntegrasesMiceMice, Inbred C57BLMice, TransgenicCre recombinaseIntegrasesAcanCell typesCerebellar nucleiClass-B cells

Identifiers

PMID42584780

DOI10.1007/s12311-026-02068-1

PMCPMC13469396

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.