Evidence map›Paper›PMID 42584711›Full record

ArticleArchives of virology2026

Pyridin-3-carbohydrazide strongly impairs Mayaro and Chikungunya virus replication in vitro.

Nancy Araceli Juárez Contreras, Natasha Marques Cassani, Mikaela Dos Santos Marinho, Giulia Magalhães Ferreira, Maria Eduarda Trevisan Aguillar da Silva, João Victor Rodrigues Dutra, Juliana Roberta Torini, Sainan Wang, Kelyssa Vitória Rodrigues Dantas, Isabela Dolci and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Nancy Araceli Juárez ContrerasLaboratory of Antiviral Research, Institute of Biomedical Science (ICBIM), Federal University of Uberlândia (UFU), Av. Amazonas, 4C Building - room 216, Uberlândia, Minas Gerais, 38405-302, Brazil.
Natasha Marques CassaniLaboratory of Antiviral Research, Institute of Biomedical Science (ICBIM), Federal University of Uberlândia (UFU), Av. Amazonas, 4C Building - room 216, Uberlândia, Minas Gerais, 38405-302, Brazil.
Mikaela Dos Santos MarinhoLaboratory of Antiviral Research, Institute of Biomedical Science (ICBIM), Federal University of Uberlândia (UFU), Av. Amazonas, 4C Building - room 216, Uberlândia, Minas Gerais, 38405-302, Brazil.
Giulia Magalhães FerreiraLaboratory of Antiviral Research, Institute of Biomedical Science (ICBIM), Federal University of Uberlândia (UFU), Av. Amazonas, 4C Building - room 216, Uberlândia, Minas Gerais, 38405-302, Brazil.
Maria Eduarda Trevisan Aguillar da SilvaFederal University of Triângulo Mineiro, Campus Universitário Iturama, Iturama, Minas Gerais, Brazil.
João Victor Rodrigues DutraFederal University of Triângulo Mineiro, Campus Universitário Iturama, Iturama, Minas Gerais, Brazil.
Juliana Roberta ToriniCenter for Research and Innovation in Biodiversity and Pharmaceuticals, São Carlos Institute of Physics (IFSC), University of São Paulo (USP), São Carlos, São Paulo, Brazil.
Sainan WangInstitute of Bioengineering, University of Tartu, Tartu, Estonia.
Kelyssa Vitória Rodrigues DantasFederal University of Triângulo Mineiro, Campus Universitário Iturama, Iturama, Minas Gerais, Brazil.
Isabela DolciCenter for Research and Innovation in Biodiversity and Pharmaceuticals, São Carlos Institute of Physics (IFSC), University of São Paulo (USP), São Carlos, São Paulo, Brazil.
Mariana Ortiz de GodoyCenter for Research and Innovation in Biodiversity and Pharmaceuticals, São Carlos Institute of Physics (IFSC), University of São Paulo (USP), São Carlos, São Paulo, Brazil.
Lavinia CiprianoCenter for Research and Innovation in Biodiversity and Pharmaceuticals, São Carlos Institute of Physics (IFSC), University of São Paulo (USP), São Carlos, São Paulo, Brazil.
Margus VarjakInstitute of Bioengineering, University of Tartu, Tartu, Estonia.
Rafaela Sachetto FernandesCenter for Research and Innovation in Biodiversity and Pharmaceuticals, São Carlos Institute of Physics (IFSC), University of São Paulo (USP), São Carlos, São Paulo, Brazil.
Rafael Victorio Carvalho GuidoCenter for Research and Innovation in Biodiversity and Pharmaceuticals, São Carlos Institute of Physics (IFSC), University of São Paulo (USP), São Carlos, São Paulo, Brazil.
Glaucius OlivaCenter for Research and Innovation in Biodiversity and Pharmaceuticals, São Carlos Institute of Physics (IFSC), University of São Paulo (USP), São Carlos, São Paulo, Brazil.
Bo ZhangKey Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Andres MeritsInstitute of Bioengineering, University of Tartu, Tartu, Estonia.
Bruno Amaral MeirelesFederal University of Triângulo Mineiro, Campus Universitário Iturama, Iturama, Minas Gerais, Brazil.
Diego Pandeló JoséFederal University of Triângulo Mineiro, Campus Universitário Iturama, Iturama, Minas Gerais, Brazil.
Ana Carolina Gomes JardimLaboratory of Antiviral Research, Institute of Biomedical Science (ICBIM), Federal University of Uberlândia (UFU), Av. Amazonas, 4C Building - room 216, Uberlândia, Minas Gerais, 38405-302, Brazil. jardim@ufu.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alphaviruses, including Mayaro virus (MAYV) and Chikungunya virus (CHIKV), pose a growing public health threat, with increasing reports worldwide and no licensed antiviral treatments available. This study evaluated the antiviral activity of pyridine-3-carbohydrazide (P-3-C) against MAYV (strains BeAr and TRVL) and CHIKV (strain La Reunion, LR). Vero E6 or U-2OS cells were infected and treated with P-3-C for 24 h, and cell viability and replication levels were assessed. The 50% cytotoxic concentration (CC

Indexed as

AlphavirusAntiviral AgentsChikungunya virusHydrazinesPyridinesVirus ReplicationAnimalsCell LineCell SurvivalChlorocebus aethiopsHumansMolecular Docking SimulationRNA, ViralVero CellsViral Nonstructural ProteinsAntiviral AgentscarbohydrazideHydrazinesPyridinesRNA, ViralViral Nonstructural Proteins

Identifiers

PMID42584711
PMCPMC13469200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.