Evidence map›Paper›PMID 42584545›Full record

SynthesisJournal of robotic surgery2026

Transoral robotic surgery for glottic squamous cell carcinoma: a systematic review and patient-level analysis of surgical, functional, and oncologic outcomes.

Pierre Guarino, Andrea Luigi Camillo Carobbio, Valentina Camesasca, Stefano De Rossi, Elisa Laura, Alfredo Lo Manto, Giampiero Salonna, Edoardo Serafini, Barbara Verro, Francesco Chiari

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of robotic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pierre Guarino *Otolaryngology Head and Neck Unit, "Santo Spirito" Hospital, Pescara, Via Fonte Romana 8, 65124, Pescara, PE, Italy. pierreguarino@hotmail.com.ORCID https://orcid.org/0000-0003-3796-9483
Andrea Luigi Camillo Carobbio *Unit of Otorhinolaryngology - Head and Neck Surgery, Azienda Ospedale-Università Di Padova, Padua, Italy.
Valentina CamesascaDepartment of Otolaryngology and Head & Neck Surgery, Grande Ospedale Metropolitano Niguarda - Centro Clinico NEMO (NeuroMuscolar Omnicenter), Milan, Italy.
Stefano De RossiDepartment of Otorhinolaryngology and Head & Neck Surgery, Mater Salutis Hospital, Legnago, Italy.
Elisa LauraOtolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Treviso, Italy.
Alfredo Lo MantoDepartment of Otorhinolaryngology - Head and Neck Surgery, Ospedale Infermi, Rimini, Italy.
Giampiero SalonnaOtorhinolaringology Unit, Cardinal Panico Hospital - Tricase, Lecce, Italy.
Edoardo SerafiniDepartment of Otolaryngology - Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
Barbara VerroDepartment of Biomedicine, Neuroscience and Advanced Diagnostic, Division of Otorhinolaryngology, University of Palermo, Palermo, Italy.
Francesco ChiariOtolaryngology Head and Neck Unit, "Santo Spirito" Hospital, Pescara, Via Fonte Romana 8, 65124, Pescara, PE, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence regarding the role of transoral robotic surgery (TORS) in glottic squamous cell carcinoma (GLSCC) remains limited. This systematic review aimed to evaluate the surgical, functional, and oncologic outcomes of TORS for GLSCC through a patient-level analysis. A PRISMA-compliant systematic review was conducted using PubMed, Scopus, and the Cochrane Library through 31 May 2026. Surgical, functional, and oncologic outcomes were extracted, and Kaplan-Meier analyses were performed when patient-level follow-up data were available. Fifteen studies including 134 patients were analyzed, comprising 91 robotic cordectomies, 21 robotic partial laryngectomies, and 22 robotic total laryngectomies. Robotic cordectomy was associated with short operative times (20.0 ± 10.8 min), minimal blood loss (13.2 ± 9.0 mL), and a low conversion rate (2.2%). Temporary tracheostomy, and feeding tube dependence occurred in 4.4%, and 12.4%, respectively. Robotic partial laryngectomy demonstrated favorable functional outcomes, with successful decannulation and feeding tube removal reported in all available cases. Five-year local control, disease-specific survival, and overall survival following robotic cordectomy were 86.5%, 97.5%, and 93.6%, respectively. In the robotic total laryngectomy cohort, 5-year local, regional, and distant disease control rates exceeded 90%, although oncologic outcomes for robotic partial laryngectomy could not be reliably assessed because of insufficient follow-up data. TORS appears to be a feasible treatment option for selected patients with GLSCC, providing encouraging surgical, functional, and oncologic outcomes. However, the available evidence remains limited to small retrospective studies, and larger comparative investigations are needed to better define its role in clinical practice.

Indexed as

Carcinoma, Squamous CellGlottisLaryngeal NeoplasmsLaryngectomyNatural Orifice Endoscopic SurgeryRobotic Surgical ProceduresHumansOperative TimeTreatment OutcomeFunctional outcomesGlottic carcinomaLaryngeal neoplasmsOncologic outcomesTransoral robotic surgery

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.