Evidence map›Paper›PMID 42584475›Full record

ArticleNanoscale2026

Body mass index-specific nanoparticle protein corona signatures in late pregnancy.

Samantha Velazquez, Matthew C Juber, Michele Okun, Edward Lau, Ali Akbar Ashkarran

Abstract read
PubMed Publisher
In one paragraph

Article in Nanoscale, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Samantha VelazquezDepartment of Biology, University of Colorado Colorado Springs, Colorado Springs, CO, USA.
Matthew C JuberDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA. edward.lau@cuanschutz.edu.ORCID http://orcid.org/0000-0002-8757-7763
Michele OkunSleep and Biobehavioral Health Research Laboratory, BioFrontiers Center, University of Colorado Colorado Springs, Colorado Springs, CO, USA. mokun@uccs.edu.
Edward LauDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA. edward.lau@cuanschutz.edu.ORCID http://orcid.org/0000-0001-9083-5922
Ali Akbar AshkarranDepartment of Physics and Energy Science, University of Colorado Colorado Springs, Colorado Springs, CO, USA. aashkarr@uccs.edu.ORCID http://orcid.org/0000-0001-7883-6690

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The protein corona (PC) formed on the surface of nanoparticles (NPs) upon exposure to human biofluids is a dynamic interface that reflects the physiological and pathological status of the host. In this study, we investigated how the maternal body mass index (BMI) influences the composition of the NPs' PC during late pregnancy. Polystyrene NPs were incubated with plasma samples collected from third-trimester pregnant individuals across normal weight, overweight, and obese BMI categories. Comprehensive characterization using dynamic light scattering (DLS), zeta potential measurements, and transmission electron microscopy (TEM) confirmed BMI-dependent differences in PC thickness and colloidal stability. SDS-PAGE and label-free quantitative proteomics revealed distinct molecular compositions: PCs from obese individuals were enriched in inflammatory and lipid metabolism-associated proteins (

Indexed as

Body Mass IndexNanoparticlesProtein CoronaAdultFemaleHumansObesityPolystyrenesPregnancyPregnancy Trimester, ThirdPrincipal Component AnalysisProteomicsPolystyrenesProtein Corona

Identifiers

PMID42584475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.