Evidence map›Paper›PMID 42584403›Full record

ArticleJournal of extracellular vesicles2026

Stress-Induced Switch in Small Extracellular Vesicle Secretion: From Constitutive 'Torn Bag Mechanism' to Exocytosis.

Dorina Lenzinger, Lilla Lankovics, István Dudás, Tünde Bárkai, Zsófia Szász, Mirjam Balbisi, Anthony Yan-Tang Wu, Krisztina V Vukman, Kelsey Fletcher, Attila Csomos and 9 more

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Article in Journal of extracellular vesicles, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Dorina LenzingerInstitute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Lilla LankovicsInstitute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
István DudásInstitute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Tünde BárkaiInstitute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Zsófia SzászInstitute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Mirjam BalbisiMTA-HUN-REN TTK Lendület (Momentum) Glycan Biomarker Research Group, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.
Anthony Yan-Tang WuInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan.
Krisztina V VukmanInstitute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Kelsey FletcherInstitute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Attila CsomosDepartment of Chemistry, Faculty of Natural Sciences, ELTE Eötvös Loránd University, Budapest, Hungary.
Zoltán MucsiFaculty of Materials and Chemical Engineering, Institute of Chemistry, University of Miskolc, Miskolc, Hungary.
Edina BugyikInstitute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Csaba CserépLaboratory of Neuroimmunology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.
Ádám DénesLaboratory of Neuroimmunology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.
Szilvia BőszeInstitute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Lilla TuriákMTA-HUN-REN TTK Lendület (Momentum) Glycan Biomarker Research Group, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.ORCID 0000-0002-2139-8156
Charles Pin-Kuang LaiInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0000-0001-8050-7060
Edit I BuzásInstitute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-3744-206X
Tamás VisnovitzInstitute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-7962-5083

Funding

Academia Sinica Academia Sinica Postdoctoral Scholar ProgramAcademia Sinica AS-CDA-109-M04Academia Sinica AS-iMATE-113-34Iams Junior Postdoctoral FellowshipMagyar Tudományos Akadémia János Bolyai Research ScholarshipMagyar Tudományos Akadémia 'Momentum' LP2022-5/2022Magyar Tudományos Akadémia 'Momentum' LP2023-19/2023Magyar Tudományos Akadémia NAP2022-I-1/2022National Science and Technology Council NSTC111-2628-B-001-022National Science and Technology Council NSTC114-2628-B-001-011National Science and Technology Council TaiwanNemzeti Kutatási Fejlesztési és Innovációs Hivatal ADVANCED_25 grant (152112)Nemzeti Kutatási Fejlesztési és Innovációs Hivatal ADVANCED_grant (150767)Nemzeti Kutatási Fejlesztési és Innovációs Hivatal EKÖP-25Nemzeti Kutatási Fejlesztési és Innovációs Hivatal Higher Education Excellence Program (FIKP)Nemzeti Kutatási Fejlesztési és Innovációs Hivatal NVKP_16-1-2016-0004Nemzeti Kutatási Fejlesztési és Innovációs Hivatal RRF-2.3.1-21-2022-00003Nemzeti Kutatási Fejlesztési és Innovációs Hivatal STARTING_25 grant (No. 152115)Nemzeti Kutatási Fejlesztési és Innovációs Hivatal TKP2021-EGA-23Nemzeti Kutatási Fejlesztési és Innovációs Hivatal VEKOP-2.3.3-15-2017-00016
6 · The paper itself

Abstract

The biogenesis of small extracellular vesicles (sEVs) is only partially understood. Our recent findings provide evidence that a newly described sEV secretion pathway, the amphiectosome release followed by the sEV discharge by the 'torn bag mechanism' are present in all tested cell lines and mouse organs. Surprisingly, in in situ fixed steady-state cells, transmission electron microscopy did not reveal sEV release via exocytosis of multivesicular endosomes (MVEs). In the current study, we extended our previous analysis to additional mouse organs and confirmed the presence of secreted amphiectosomes in all of them. Furthermore, we investigated which parameters influence the activation of the distinct sEV release mechanisms in HEK cells. Our results show that under stress conditions (such as Ca

Indexed as

ExocytosisExtracellular VesiclesStress, PhysiologicalAnimalsAutophagyAutophagy-Related Protein 5EndosomesHEK293 CellsHumansMiceMultivesicular Bodiesrab27 GTP-Binding ProteinsAutophagy-Related Protein 5rab27 GTP-Binding Proteinsamphiectosomeautophagyexocytosisexosome secretionsmall extracellular vesiclesstress‘torn bag mechanism’

Identifiers

PMID42584403
PMCPMC13464432

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.