Thrombolysis in Patients With Mild Ischemic Stroke: A Comparative Effectiveness Study From the Norwegian Stroke Registry.

Elise K Kristensen, Agnethe Eltoft, Torunn Varmdal, Bent Indredavik, Ellisiv B Mathiesen

Abstract readComparative Study

In one paragraph

Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elise K KristensenDepartment of Clinical Medicine, Faculty of Health Sciences, UiT the Arctic University, Tromsø, Norway.ORCID https://orcid.org/0009-0006-4120-2137

Agnethe EltoftDepartment of Clinical Medicine, Faculty of Health Sciences, UiT the Arctic University, Tromsø, Norway.ORCID https://orcid.org/0000-0001-9808-879X

Torunn VarmdalDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.ORCID https://orcid.org/0000-0002-1533-9651

Bent IndredavikDepartment of Medical Quality Registries, St Olav's Hospital HF, Trondheim, Norway.ORCID https://orcid.org/0000-0001-9665-9763

Ellisiv B MathiesenDepartment of Clinical Medicine, Faculty of Health Sciences, UiT the Arctic University, Tromsø, Norway.ORCID https://orcid.org/0000-0001-8887-6100

Funding

UiT The Arctic University of Norway

6 · The paper itself

Abstract

backgroundIntravenous thrombolytic therapy (IVT) is recommended for patients with acute ischemic stroke (AIS) and disabling deficits, regardless of National Institutes of Health Stroke Scale (NIHSS) score. The benefit of IVT in patients with mild AIS was, however, not documented in recent trials. The aim of this study was to evaluate the effectiveness of IVT in mild AIS in a nationwide registry-based study.

methodsAIS patients from the Norwegian Stroke Registry (2016-2022) with a National Institutes of Health Stroke Scale (NIHSS) score

resultsAt 90 days, 68.4% of IVT-treated patients and 61.2% of controls achieved mRS 0-1 (OR 1.39; 95% CI 1.20-1.60). IVT was associated with a higher probability of achieving excellent functional outcome in patients with NIHSS 4-5 (OR 1.53; 95% CI 1.06-2.21) and NIHSS 2-3 (OR 1.64; 95% CI 1.32-2.03), but not NIHSS 0-1 (OR 1.14; 95% CI 0.89-1.44). No significant differences in overall mortality were observed. SICH occurred in 3.7% of IVT-treated patients.

conclusionIVT was associated with favorable functional outcomes for mild AIS, but not in patients with NIHSS 0-1.

Indexed as

Fibrinolytic AgentsIschemic StrokeOutcome Assessment, Health CareThrombolytic TherapyAgedAged, 80 and overFemaleHumansMaleMiddle AgedNorwayRegistriesSeverity of Illness IndexTissue Plasminogen ActivatorTreatment OutcomeFibrinolytic AgentsTissue Plasminogen Activatorischemic strokemild strokeminor strokeNational Institutes of Health stroke scalethrombolytic therapy

Identifiers

PMID42584034

DOI10.1111/ene.70734

PMCPMC13463750

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.