ArticlePharmacoepidemiology and drug safety2026
Patient Characteristics and Risk of Fall-Related Injuries Among New Users of Opioids in Denmark: A Longitudinal Descriptive Study.
Article in Pharmacoepidemiology and drug safety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Patient Characteristics and Risk of Fall-Related Injuries Among New Users of Opioids in Denmark: A Longitudinal Descriptive Study.Pharmacoepidemiology and drug safety · 2026Article
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6 authors.
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Abstract
purposeTo assess the 1-year risk of fall-related injuries among new users of opioids in Denmark.
methodsUsing Danish health registers, we identified all new adult users of opioids between 2010 and 2022 (first time use within 5 years). We performed logistic regression and applied marginal comparisons to estimate risk ratios (RRs) associating baseline risk factors to any fall-related injury and fall-related fractures specifically. Patients were followed after opioid initiation until fall-related injury, death, leaving the country, or 1-year follow-up, whichever occurred first.
resultsWe identified 1 638 358 unique new users of opioids (54% women; median age 58 years). The 1-year risk of fall-related injuries and fall-related fractures was 8.6% and 3.6%, respectively. The risk of fall-related injuries was highest during the first weeks following opioid initiation. Increasing age, depression, Parkinson's disease, osteoporosis, and prior fall-related injuries were all associated with new fall-related injuries in the multivariable analysis. Prior fall-related injuries was a predictor of new fall-related injuries (RR 2.15; 95% CI: 2.12-2.18) and fall-related fractures (RR 1.35; 95% CI: 1.31-1.40). Prior fall-related fractures was a predictor of new fall-related injuries (RR 1.96; 95% CI: 1.93-1.99) and fall-related fractures (RR 6.47; 95% CI: 6.29-6.65).
conclusionThe 1-year risk for any fall-related injuries and fractures was 8.6% and 3.6%, respectively, and highest in the first weeks following opioid initiation. Several important risk factors associated with new fall-related injuries were identified. Physicians should be aware of patient characteristics related to fall risk when prescribing opioids.
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