Evidence map›Paper›PMID 42583824›Full record

ArticleeLife2026

Five-layer systems analysis of

Pascale Pescher, Thibaut Douché, Quentin Giai Gianetto, Karen Druart, Julie Kovářová, Blaise Li, Thomas Cokelaer, K Shanmugha Rajan, Laura Piel, Céline Besse and 6 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Pascale PescherInstitut Pasteur, Université Paris Cité, INSERM 1347, Unité de Parasitologie moléculaire et Signalisation, Paris, France.ORCID https://orcid.org/0000-0003-2796-7855
Thibaut DouchéInstitut Pasteur, Université Paris Cité, CNRS UAR 2024, Proteomic Platform, Mass Spectrometry for Biology Unit, Paris, France.ORCID https://orcid.org/0000-0001-8627-6726
Quentin Giai GianettoInstitut Pasteur, Université Paris Cité, CNRS UAR 2024, Proteomic Platform, Mass Spectrometry for Biology Unit, Paris, France.
Karen DruartInstitut Pasteur, Université Paris Cité, CNRS UAR 2024, Proteomic Platform, Mass Spectrometry for Biology Unit, Paris, France.
Julie KovářováGlasgow Centre for Parasitology, University of Glasgow, Glasgow, United Kingdom.ORCID https://orcid.org/0000-0001-8737-6403
Blaise LiInstitut Pasteur, Université Paris Cité, Biostatistics and Bioinformatics Hub, Paris, France.ORCID https://orcid.org/0000-0003-3080-1899
Thomas CokelaerInstitut Pasteur, Université Paris Cité, INSERM 1347, Unité de Parasitologie moléculaire et Signalisation, Paris, France.ORCID https://orcid.org/0000-0001-6286-1138
K Shanmugha RajanWeizmann Institute of Science, Department of Chemical and Structural Biology, Rehovot, Israel.ORCID https://orcid.org/0000-0003-4826-9802
Laura PielInstitut Pasteur, Université Paris Cité, INSERM 1347, Unité de Parasitologie moléculaire et Signalisation, Paris, France.
Céline BesseUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France.
Anne BolandUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France.
Jean-François DeleuzeUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France.ORCID https://orcid.org/0000-0002-5358-4463
Mariette MatondoInstitut Pasteur, Université Paris Cité, CNRS UAR 2024, Proteomic Platform, Mass Spectrometry for Biology Unit, Paris, France.ORCID https://orcid.org/0000-0003-3958-7710
Michael P BarrettGlasgow Centre for Parasitology, University of Glasgow, Glasgow, United Kingdom.
Shulamit MichaeliBar-Ilan University, Mina and Everard Goodman Faculty of Life Sciences and Advanced and Nanotechnology Institutee, Ramat-Gan, Israel.ORCID https://orcid.org/0000-0002-9895-0439
Gerald F SpäthInstitut Pasteur, Université Paris Cité, INSERM 1347, Unité de Parasitologie moléculaire et Signalisation, Paris, France.ORCID https://orcid.org/0000-0002-0256-2029

Funding

Agence Nationale de la Recherche ANR-10-INBS-09Agence Nationale de la Recherche ANR-10-LABX-62-IBEIDAgence Nationale de la Recherche ANR-11-LABX-0024European Research Council 10.3030/101071613
6 · The paper itself

Abstract

Vector-borne, protist parasites have evolved complex developmental programs to adapt to very distinct host environments. How these important pathogens transition between insect and mammalian stages is only poorly understood. Here, we investigated stage differentiation in

Indexed as

Leishmania donovaniProteolysisProtozoan ProteinsAnimalsCell DifferentiationCricetinaeGene Expression ProfilingProteomicsProtozoan Proteinsinfectious diseaseLeishmania donovanimicrobiologyprotein degradationregulatory networksstage differentiationsystems analysis

Identifiers

PMID42583824
PMCPMC13466544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.