Evidence map›Paper›PMID 42583783›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Vulnerability of locus coeruleus connections to aging and Alzheimer's disease.

Blanca Zufiria-Gerbolés, Daniel Vereb, Mite Mijalkov, Massimiliano Passaretti, Giovanni Volpe, Zhilei Xu, Thomas Hinault, Sara Garcia-Ptacek, Joana B Pereira, Alzheimer's Disease Neuroimaging Initiative

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Vulnerability of locus coeruleus connections to aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Blanca Zufiria-GerbolésDepartment of Clinical Neuroscience, Division of Neuro, Karolinska Institutet, Stockholm, Sweden.
Daniel VerebDepartment of Clinical Neuroscience, Division of Neuro, Karolinska Institutet, Stockholm, Sweden.
Mite MijalkovDepartment of Clinical Neuroscience, Division of Neuro, Karolinska Institutet, Stockholm, Sweden.
Massimiliano PassarettiDepartment of Clinical Neuroscience, Division of Neuro, Karolinska Institutet, Stockholm, Sweden.
Giovanni VolpeDepartment of Physics, Goteborg University, Goteborg, Sweden.
Zhilei XuDepartment of Clinical Neuroscience, Division of Neuro, Karolinska Institutet, Stockholm, Sweden.
Thomas HinaultUNICAEN, PSL Université Paris, Paris, France.
Sara Garcia-PtacekDepartment of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Joana B PereiraDepartment of Clinical Neuroscience, Division of Neuro, Karolinska Institutet, Stockholm, Sweden.
Alzheimer's Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Alzheimer FoundationBrain Foundation 2022-014Center for Medical Innovation (CIMED)European Union - NextGenerationEU and the Romanian Government, under National Recovery and Resilience Plan for RomaniaFoundation for Geriatric Diseases at Karolinska InstitutetGamla TjänarinnorInnovative ways to fight Alzheimer´s disease - Leif Lundblad Family and othersKarolinska InstitutetKIConsolidator grantKID-fundingKonungGustaf V:s och Drottning Victorias StiftelseLars Hiertas Memorial FoundationNational Academic Infrastructure for Super-computing in SwedenNIA NIH HHS U01 AG024904Romanian Ministry of Research, Innovation and Digitalization, within Component 9,Investment I8Stohnes FoundationStrategic Research Area Neuroscience (StratNeuro)Swedish Research Council 2022-01108Swedish ResearchCouncil 2022-06725
6 · The paper itself

Abstract

introductionThe locus coeruleus (LC) is important in coordinating communication between brain regions through its widespread connections. However, the organization of its connections, and its changes with aging and Alzheimer's disease (AD), remains unclear.

methodsWe mapped whole-brain white matter connections from the LC in two independent cohorts: one spanning the adult lifespan and another covering the AD continuum.

resultsWe identified a novel dorsal-ventral organization of LC connectivity that showed changes common to aging and AD or specific to AD, was linked to gene expression patterns, and was associated with cognitive performance and tau pathology in the entorhinal cortex. We also developed an imaging marker, LC gap, capturing LC connectivity deviations associated with slower tau accumulation in cognitively normal individuals at high risk for AD. DISCUSSION: These findings provide new insights into LC connectivity in aging and AD, highlighting its potential role as a resilience marker against AD neurodegeneration.

Indexed as

AgingAlzheimer DiseaseLocus CoeruleusAdultAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural Pathwaystau ProteinsWhite Mattertau ProteinsagingAlzheimer's diseasebrain connectivitylocus coeruleusneuromodulatory nucleiTau pathology

Identifiers

PMID42583783
PMCPMC13463321

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.