Evidence map›Paper›PMID 42583748›Full record

ArticleJournal of internal medicine2026

Selective glomerular hypofiltration is associated with glucometabolic disturbances in the general population.

Christopher Nilsson, Agne Laucyte-Cibulskiene, Amra Jujic, Marcus A Ohlsson, Gregor Guron, Maria K Svensson, Maria Weiner, P Andreas Jonsson, Johan Ärnlöv, Gunnar Engström and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Christopher NilssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0001-8399-8854
Agne Laucyte-CibulskieneDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0003-4020-1467
Amra JujicDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0002-9506-0158
Marcus A OhlssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0003-0043-1727
Gregor GuronDepartment of Molecular and Clinical Medicine/Nephrology, Institute of Medicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Maria K SvenssonDepartment of Medical Sciences, Renal Medicine, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0001-7545-5585
Maria WeinerDepartment of Medicine, Health and Caring Sciences, Linköping University, Linköping, Sweden.ORCID https://orcid.org/0000-0001-8183-3984
P Andreas JonssonDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.ORCID https://orcid.org/0000-0002-1938-0707
Johan ÄrnlövDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-6933-4637
Gunnar EngströmDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Anders GrubbDepartment of Clinical Chemistry, Skåne University Hospital, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0002-0125-3662
Anders LarssonDepartment of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0003-3161-0402
Martin MagnussonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0003-1710-5936
Anders ChristenssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0002-7328-8418

Funding

Crafoord FoundationCrafoordska StiftelsenErnhold Lundstroms Research FoundationErnhold Lundströms stiftelseGreta och Johan Kocks stiftelserHjärt-LungfondenHulda and Conrad Mossfelt FoundationHulda och E Conrad Mossfelts Stiftelse för Vetenskaplig Forskning Inom Hjärt- och Kärlsjukdomarnas OmrådeKockska FoundationLund UniversityMedical Faculty of Lund UniversityRegion SkaneResearch and Development Council of Region SkåneResearch Funds of Region SkåneSkånes universitetssjukhusSkane University HospitalSkåne University Hospital Research FundSouthwest Skanes Diabetes FoundationSwedish Heart and Lung Foundation 2024-0979Swedish Kidney FoundationSwedish Research Council 2022-00973VetenskapsrådetWallenberg Center for Molecular MedicineWallenberg Centre for Molecular and Translational Medicine
6 · The paper itself

Abstract

backgroundDiscordance between cystatin C- and creatinine-based estimated glomerular filtration rate (eGFR) has been linked to adverse outcomes. A low eGFR

methodsIn 28,078 participants aged 50-64 years from the Swedish CArdioPulmonary bioImage Study, we assessed glycemic status (normoglycemia, prediabetes, and diabetes), hemoglobin A1c (HbA1c), fasting glucose, and insulin resistance (homeostatic model assessment of insulin resistance [HOMA-IR]). Outcomes were the continuous eGFR

resultsMean eGFR

conclusionsDysglycemia and insulin resistance were associated with a lower eGFR

Indexed as

Glomerular Filtration RateBiomarkersBlood GlucoseCreatinineCystatin CFemaleGlycated HemoglobinHumansInsulin ResistanceMaleMiddle AgedPrediabetic StateSwedenBiomarkersBlood GlucoseCreatinineCystatin CGlycated Hemoglobincreatininecystatin Cdiabetesdiabetic kidney diseaseglomerular filtration rateinsulin resistance

Identifiers

PMID42583748
PMCPMC13569112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.