ArticleAnnals of medicine and surgery (2012)2026
Preoperative serum albumin levels as predictors of postoperative morbidity in pediatric congenital heart surgery: a retrospective cohort study.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Severe congenital heart disease often requires cardiopulmonary bypass (CPB) surgery. Preoperative hypoalbuminemia may adversely affect postoperative recovery; however, the dose-response relationship between preoperative serum albumin levels and early postoperative adverse events remains unclear. Methods: This retrospective cohort study included 1033 pediatric patients with congenital heart disease who underwent CPB surgery between 2018 and 2024. The primary exposure was the preoperative serum albumin level. The primary outcome was early postoperative adverse events, defined as a composite endpoint including mortality, reintubation, prolonged mechanical ventilation, and extended hospitalization. Patients without these events were classified as the non-adverse outcome group. Multivariable logistic regression models were used to evaluate the association between preoperative albumin levels and postoperative outcomes. Restricted cubic spline (RCS) analysis was performed to assess potential nonlinear relationships. Subgroup analyses based on relevant baseline characteristics were considered exploratory and hypothesis-generating. Results: In the fully adjusted model, compared with the lowest quartile, the second and fourth quartiles of preoperative albumin were associated with significantly lower risks of adverse postoperative outcomes, with odds ratios (ORs) of 0.542 (95% CI: 0.328-0.889) and 0.466 (95% CI: 0.268-0.795), respectively. RCS analysis demonstrated a gradual reduction in adverse outcome risk with increasing albumin levels, with the protective effect plateauing at approximately 40.65 g/L. When albumin levels were ≤40.65 g/L, each incremental increase was associated with a significantly reduced risk of adverse outcomes (OR = 0.864; 95% CI: 0.755-0.983; Conclusions: Preoperative serum albumin levels were nonlinearly associated with early postoperative adverse outcomes in pediatric patients undergoing congenital heart surgery. Higher albumin levels within the lower-to-mid physiological range were associated with improved postoperative outcomes, whereas further increases provided no additional apparent benefit. These findings are exploratory and require confirmation in prospective multicenter studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.