Evidence map›Paper›PMID 42583597›Full record

ArticleJournal of restorative medicine2026

Psychobiotic Strategies for Managing Anxiety, Depression, and Schizophrenia: A Narrative Review.

Abby Thexton, Liberty Mackay, Alexandra Vita, Rebecca Heron, Jamie Menzel, Kate Patterson, Heather Zwickey

Abstract read
In one paragraph

Article in Journal of restorative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abby Thexton
Liberty Mackay
Alexandra Vita
Rebecca Heron
Jamie Menzel
Kate Patterson
Heather Zwickey

Funding

RAND REACH CenterU24AT012549 · NCCIH · RAND CORPORATION · PI COULTER, IAN DOUGLASS, HERMAN, PATRICIA M · 2023 to 2025
$6.2M
Building Research across Interdisciplinary Gaps (BRIDG) R90 Training Program - Administrative SupplementR90AT008924 · NCCIH · NATIONAL UNIVERSITY OF NATURAL MEDICINE · PI BRADLEY, RYAN D, ZWICKEY, HEATHER LEA · 2015 to 2025
$5.2M
Evidence-based Nutrition Education and Research Guidance (ENER-G)R25DK130848 · NIDDK · NATIONAL UNIVERSITY OF NATURAL MEDICINE · PI Clinton D Allred, Heather Lea Zwickey · 2023 to 2026
$425k
NCCIH NIH HHS R90 AT008924NCCIH NIH HHS U24 AT012549NIDDK NIH HHS R25 DK130848
6 · The paper itself

Abstract

The gut microbiome exerts significant influence over mental health through the bidirectional communication network of the gut-brain axis. Growing evidence implicates disruptions in gut microbial composition in the pathophysiology of a range of neuropsychiatric conditions, including anxiety, major depressive disorder (MDD), and schizophrenia. Psychobiotics have emerged as a promising adjunctive strategy for modulating mental health outcomes through several interconnected mechanisms, including neurotransmitter modulation, immune regulation, short-chain fatty acid production, and hypothalamic-pituitary-adrenal axis stabilization, among others. This narrative review, intended for clinicians and researchers in integrative and functional medicine, synthesizes current clinical and translational evidence for probiotic interventions across anxiety, MDD, bipolar disorder, and schizophrenia, highlighting key strains, mechanisms, and outcomes. Findings demonstrate that specific

Identifiers

PMID42583597
PMCPMC13461240

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.