ArticleJournal of surgical case reports2026
A giant intramuscular myolipoma of the gluteus maximus mimicking well-differentiated liposarcoma: a diagnostic challenge.
Article in Journal of surgical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Myolipoma is an exceptionally rare benign mesenchymal neoplasm composed of mature adipose tissue admixed with smooth muscle elements. We report a 67-year-old male who presented with a 3-month history of a progressive, painless mass in the right gluteal region. Ultrasound and magnetic resonance imaging revealed a large (125 × 88 × 60 mm) encapsulated intramuscular mass with thick enhancing septations and restricted diffusion, raising high suspicion for well-differentiated liposarcoma. Two sequential ultrasound-guided core needle biopsies were non-diagnostic. Complete surgical excision was performed; intraoperative findings demonstrated a well-encapsulated lesion with no invasion of surrounding structures. Definitive histopathology confirmed a benign intramuscular myolipoma. This case underscores that large deep-seated myolipomas can radiologically mimic liposarcoma, that percutaneous biopsy may be non-representative, and that surgical excision remains both the definitive diagnostic and therapeutic gold standard.
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