ArticleAnnals of medicine and surgery (2012)2026
Effects of prophylactic tranexamic acid on bleeding during transbronchial lung biopsy: a double-blind, randomized controlled trial.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: This randomized controlled trial evaluated the efficacy of tranexamic acid in preventing bleeding in patients undergoing transbronchial lung biopsy. Materials and methods: This study was a double-blind, parallel-group, randomized controlled trial. Adult patients referred for flexible bronchoscopy with a planned transbronchial lung biopsy during 2024 were included in the current study. Participants in the intervention group received 10 mg/kg of intravenous tranexamic acid in normal saline, administered 20 minutes prior to the procedure. Those in the placebo group received an equal volume of normal saline. We assessed the need for bleeding control interventions, such as epinephrine or ice saline use, the incidence of tachycardia or hypotension, uncontrolled bleeding, and procedure length. We also measured the hemoglobin levels before and after the procedure. Results: In total, 60 patients - 32 (53.3%) in the tranexamic acid group and 28 (46.7%) in the control group - were enrolled in the study. The percentage of females (53.6% vs. 28.1%) and the mean age of participants (66.5 vs. 42.9 years) were significantly higher in the control group compared to the tranexamic acid group ( Conclusions: Tranexamic acid can be effective in preventing bleeding in individuals undergoing transbronchial lung biopsy and in enhancing procedural speed.
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