ArticleAnnals of medicine and surgery (2012)2026
Robot-assisted Ivor-Lewis esophagectomy with intrathoracic anastomosis for adenocarcinoma of the esophagogastric junction: a cohort study of 156 cases.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To compare the efficacy and safety of neoadjuvant therapy (NT) followed by robot-assisted Ivor-Lewis esophagectomy vs. upfront surgery (S) in patients with locally advanced adenocarcinoma of the esophagogastric junction (AEG). Methods: We retrospectively analyzed 156 patients with locally advanced AEG (cT2-4a/N0-2) who underwent robot-assisted Ivor-Lewis surgery with intrathoracic anastomosis between 2017 and 2024. Baseline characteristics, pathological responses, and surgical outcomes were compared between the NT and S groups. Survival data were evaluated using Kaplan-Meier analysis. Results: Of the 156 patients, 41 (26.3%) received NT. The NT group achieved a pathological complete response (pCR) rate of 24.4% (vs. 0% in the S group) and higher node-negative rates (pN0: 56.1% vs. 32.2%, Conclusion: NT significantly improves pathological responses and survival in advanced AEG without increasing surgical risks. The robotic-assisted approach enables the safe implementation of this multimodal treatment strategy. Visual Abstract: http://links.lww.com/MS9/B274.
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