ArticleBlood. Red cells & iron2026
Sickle red blood cell/Siglec-9 interactions contribute to neutrophil activation in SCD and are associated with survival.
Article in Blood. Red cells & iron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sialic acid-binding Ig-like lectin-9 (Siglec-9) is a neutrophil inhibitory receptor. Prior studies have shown that sickle red blood cells (SS RBCs) abnormally engage neutrophil Siglec-9, suggesting that SS RBCs may not be able to effectively inhibit neutrophil activation. We examined SS RBC/Siglec-9 interactions and determined the effect of SS RBCs on Siglec-9 expression and neutrophil function. Using a novel monoclonal antibody-specific immobilization of erythrocyte antigen (MAIEA) assay, we demonstrated that SS RBCs have significantly decreased glycophorin A (GPA) and glycophorin B (GPB)-mediated binding to Siglec-9. Furthermore, exposure of healthy neutrophils to SS RBCs but not healthy AA RBCs induced shedding of Siglec-9 from neutrophil surfaces
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