Evidence map›Paper›PMID 42583280›Full record

ArticleAnnals of medicine and surgery (2012)2026

Perioperative teriparatide in adult spinal deformity: a retrospective comparative cohort study.

Negin Safari Dehnavi, Sadegh Bagherzadeh, Diego Soto Rubio, Ashley Rogers Lorimer, Dana Saleh, Gautam Rao, Ryan Screven, Gersham Rainone, Puya Alikhani, Mohsen Rostami

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Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Negin Safari DehnaviDepartment of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Sadegh BagherzadehDepartment of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Diego Soto RubioDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Ashley Rogers LorimerDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Dana SalehDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Gautam RaoDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Ryan ScrevenDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Gersham RainoneDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Puya AlikhaniDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Mohsen RostamiDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Adults with low bone mineral density (BMD) face higher risks of implant loosening, pseudarthrosis, and junctional complications following long-segment spinal deformity reconstruction. Teriparatide (TPTD), an anabolic agent that enhances bone formation, may improve fixation strength and fusion quality. This study compared outcomes between patients with low BMD who received perioperative TPTD and those with normal BMD undergoing long-segment adult spinal deformity (ASD) surgery. Methods: In a retrospective comparative cohort study, 50 consecutive adults who underwent thoracolumbar fusion with pelvic fixation between June 2022 and January 2024 were included. Patients were classified into two cohorts: normal BMD ( Results: Baseline characteristics were similar, except for lower BMD in the TPTD group (mean T-score -1.7 vs 0.95, Conclusions: Perioperative TPTD in low-BMD patients demonstrated similar clinical, radiographic, and complication outcomes to those of patients with normal bone density undergoing long-segment ASD reconstruction. These results contribute to the role of structured bone-health optimization in ASD surgery but cannot be attributed to TPTD alone.

Indexed as

adult spinal deformitypostoperative complicationsspinal fusionteriparatide

Identifiers

PMID42583280
PMCPMC13461092

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