ArticleJournal of thoracic disease2026
Prevalence, longitudinal trajectory, and mortality of preserved ratio impaired spirometry (PRISm) in a Thai hospital-based cohort study.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Preserved ratio impaired spirometry (PRISm) is spirometric pattern characterized by reduced forced expiratory volume in 1 second (FEV1) despite a preserved FEV1/forced vital capacity (FVC) ratio. PRISm has been associated with respiratory symptoms, impaired lung function, and increased mortality; however, data from Southeast Asian populations remain limited. This study aimed to determine the prevalence, spirometric trajectory, contributing factors, and mortality of PRISm in a Thai hospital-based cohort. Methods: We conducted a retrospective cohort study of adults who underwent spirometry at Siriraj Pulmonary Function Laboratory between April 2017 and February 2018, with follow-up through March 2024. PRISm was defined using either: (I) lower limit of normal (LLN) criteria: FEV1 < LLN, FVC ≥ LLN and FEV1/FVC ≥ LLN; or (II) fixed-ratio criteria: FEV1 <80% predicted, FVC ≥80% predicted and FEV1/FVC ≥75% for age ≤45 years or ≥70% for age >45 years. Demographic characteristics, co-morbidities, trajectories and mortality were analyzed. Logistic regression and survival analyses were performed. Results: Among 1,300 subjects, the overall prevalence of PRISm was 8.4% when either definition was applied. The prevalence was 3.5% using LLN criteria, and 6.0% using fixed-ratio criteria. Compared with normal spirometry, those with PRISm were older age and had a higher prevalence of congestive heart failure. PRISm was associated with increased all-cause mortality compared with normal [hazard ratio (HR) 2.37, 95% confidence interval (CI): 1.19-4.72, P=0.001] and remained independently associated after adjustment (aHR 2.08, 95% CI: 1.04-4.15, P=0.04). Among 52 subjects with follow-up spirometry, 30.8% transitioned to normal, 28.9% developed obstructive impairment, 19.2% developed restrictive impairment, and 21.1% remained PRISm. Conclusions: PRISm is a clinically relevant spirometric pattern associated with increased mortality in this Thai cohort. Its dynamic trajectory highlights the importance of longitudinal monitoring and further research to clarify its natural history.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.