Evidence map›Paper›PMID 42583080›Full record

ArticleNoro psikiyatri arsivi2026

Corticospinal Excitability After Continuous and Intermittent Theta Burst Stimulation Applied on the Lateral Cerebellum: A Study on Healthy Individuals.

Filiz Azman İste, Vildan Yayla, Arsida Bajrami, Nejla Sözer, Aslı Demirtaş Tatlıdede, Ali Emre Öge

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Article in Noro psikiyatri arsivi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Filiz Azman İsteDepartment of Neurology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Vildan YaylaDepartment of Neurology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Arsida BajramiDepartment of Neurology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Nejla SözerDepartment of Neurology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Aslı Demirtaş TatlıdedeDepartment of Neurology, Bahcesehir University School of Medicine, Istanbul, Türkiye.
Ali Emre ÖgeDepartment of Neurology and Neurophysiology, Istanbul University, Istanbul Faculty of Medicine, İstanbul, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: To investigate the effects of continuous (cTBS) and intermittent (iTBS) theta burst stimulation applied over the lateral cerebellum on corticospinal excitability in healthy individuals. Methods: Twenty right-handed healthy male participants underwent three TBS sessions (cTBS, iTBS, sham) in a randomized crossover design. Motor evoked potentials (MEPs), resting and active motor threshold (RMT and AMT, respectively), and cortical silent period (CSP) were assessed before and after each session using single-pulse transcranial magnetic stimulation over the left primary motor cortex. Transcranial magnetic stimulation was delivered to the right cerebellar hemisphere at 80% of active motor threshold. Results: A significant reduction in MEP amplitude was observed following iTBS (p=0.028), while no significant changes occurred after cTBS or sham stimulation. No significant effects were found in RMT or CSP across any of the protocols. All sessions were well tolerated and considered safe. Mild and transient side effects, such as neck discomfort or headache, were reported in five participants. Conclusion: Intermittent cerebellar TBS was associated with reduced MEP amplitude, suggesting decreased corticospinal excitability, whereas cTBS and sham stimulation did not produce significant effects. Cerebellar TBS was safe and well tolerated in all participants. These findings suggest that cerebellar iTBS may exert modulatory effects on motor cortical excitability and may contribute to a better understanding of cerebellar stimulation effects in healthy individuals.

Indexed as

cerebellar TMScerebellumcorticospinal excitabilitytheta burst stimulationtranscranial magnetic stimulation

Identifiers

PMID42583080
PMCPMC13459179

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.