Evidence map›Paper›PMID 42583072›Full record

ReviewFrontiers in immunology2026

Extracellular vesicle-mediated immune-metabolic crosstalk: research advances in inflammatory regulation and the pathogenesis of metabolic diseases.

Hao-Ran Wang, Xue-Hui Lv, Yue Sun, Zhi-Chao Gu, Meng Lin, Le Guan, Qing-Feng Wang, Shi-Meng Wang

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hao-Ran Wang *Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Xue-Hui Lv *Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Yue SunLiaoning University of Traditional Chinese Medicine, Shenyang, China.
Zhi-Chao GuLiaoning University of Traditional Chinese Medicine, Shenyang, China.
Meng LinLiaoning University of Traditional Chinese Medicine, Shenyang, China.
Le GuanLiaoning University of Traditional Chinese Medicine, Shenyang, China.
Qing-Feng WangLiaoning University of Traditional Chinese Medicine, Shenyang, China.
Shi-Meng WangThe Fourth Affiliated Hospital of China Medical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs)-lipid bilayer-enclosed nanoparticles secreted by virtually all cell types-have shifted from being viewed as passive cellular byproducts to active signaling nodes orchestrating inter-cellular and inter-organ communication. Yet the field has accumulated faster than it has integrated: hundreds of EV-cargo-phenotype associations exist as isolated edges of a network whose system-level architecture remains poorly defined. Here we propose the

Indexed as

Extracellular VesiclesInflammationMetabolic DiseasesAnimalsHumanscausality frameworkextracellular vesiclesimmune–metabolic crosstalkinsulin resistancemacrophage polarizationMASLDmetaflammationvesiculome

Identifiers

PMID42583072
PMCPMC13459101

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.