ArticleFrontiers in microbiology2026
Chronic alcohol consumption-induced alterations in gut microbiota disrupt the integrity of the intestinal barrier.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chronic alcohol consumption is known to compromise the intestinal barrier and disrupt gut homeostasis, contributing to increased vulnerability to various diseases; however, the precise mechanisms remain poorly understood. Emerging evidence suggests that alcohol-induced alterations in host metabolism and gut microbiota composition play a critical role in driving intestinal barrier dysfunction. In this study, we employed a mouse model of chronic alcohol gavage to investigate these interactions. Untargeted metabolomics analysis revealed significant perturbations in isoflavone metabolism caused by chronic alcohol exposure. These metabolic disturbances were accompanied by notable shifts in gut microbiota composition, including an enrichment of
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