ArticleTranslational andrology and urology2026
Thiram inhibits human sperm motility and capacitation by increasing mitochondrial O
Article in Translational andrology and urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Environmental chemicals may suppress sperm motility (SM), hyperactivation, and capacitation, thus contributing to male infertility. This investigation was designed to examine the impacts of thiram on human SM and capacitation. Methods: We incubated the fungicide thiram with normal human spermatozoa to investigate sperm metrics. Results: Thiram markedly suppressed SM and hyperactivation, demonstrating half maximum effective concentration (EC Conclusions: Thiram causes irreversible inhibition of human SM, FM, and capacitation through elevation of mitochondrial superoxide anion levels and reduction of TPK and PAK4 activity, and may also act downstream of cAMP signaling, while compromising mitochondrial ultrastructural integrity.
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