ArticleIranian journal of otorhinolaryngology2026
Effects of Curcumin in Workers with Noise-Induced Hearing Loss: Preliminary Report.
Article in Iranian journal of otorhinolaryngology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Prolonged loud noise exposure causes sensorineural hearing loss through cochlear oxidative stress, requiring heat shock protein 70 (HSP70) for protection. Curcumin boosts antioxidant expression and safeguards the cochlea. Pure tone audiometry (PTA) measures the type of hearing loss and otoacoustic emission (OAE) detects early auditory issues. This study evaluated the impact of Curcumin on noise-exposed workers via PTA, OAE, and HSP70. Materials and Methods: This preliminary study included 54 noise-exposed workers with hearing thresholds ≥26 dB and SNR values <6 dB. Participants were randomized into three noise-exposed groups: placebo (positive control), 500 mg Curcumin, or 1,000 mg Curcumin for 4 weeks. A negative control group of 18 non-exposed workers with normal hearing who received no treatment, served as an external reference only. HSP70 levels, PTA, and OAE were measured before and after intervention in all groups. Results: PTA showed a significant worsening of hearing threshold in the positive control group (p=0.001), significant improvement in Curcumin 500 mg group (p=0.046), in the Curcumin 1,000 mg (p=0.059). OAE revealed substantial worsening of SNR in the positive control group (p<0.001) and significant increase in the Curcumin 500 mg (p<0.05) at 4, 7, 8, and 9 kHz, and in the 1,000 mg groups (p<0.05) at 5, 8, and 9 kHz. HSP70 levels significantly increased in the positive control group (p=0.021), both Curcumin groups showed a non-significant increase. Conclusion: Curcumin was associated with improved hearing thresholds and favorable SNR changes in noise-exposed workers. Changes in HSP70 levels were minimal and not statistically significant in the curcumin groups.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.