Evidence map›Paper›PMID 42582940›Full record

ReviewESMO gastrointestinal oncology2026

Patients' perspective in anal cancer.

S Manfrida, L Dinapoli, V De Luca, G Chiloiro, A Romano, D P R Chieffo, E Segelov, P Franco, M A Gambacorta

Abstract readReview
In one paragraph

Review in ESMO gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

S ManfridaDepartment of Radiology and Radiation Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
L DinapoliClinical Psychology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
V De LucaDepartment of Radiology and Radiation Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
G ChiloiroDepartment of Radiology and Radiation Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
A RomanoDepartment of Radiology and Radiation Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
D P R ChieffoClinical Psychology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
E SegelovDepartment of Clinical Research, Faculty of Medicine, University of Bern, Bern, Switzerland.
P FrancoDepartment of Radiation Oncology, "Maggiore della Carità" University Hospital, Novara, Italy.
M A GambacortaDepartment of Radiology and Radiation Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high chance for an anal cancer patient to be a long-term survivor stresses the importance of quality of life (QoL) after treatment. Radiation therapy targeting the anal canal can impair anorectal, urinary, and sexual functions. Patients' viewpoints regarding their overall care experiences are aimed at improving information for both patients and healthcare providers to address their unmet needs. This review examines patient perspectives from diagnosis through survivorship, encompassing physical and psychological impacts, side-effect management, and transitioning to survivorship. Two cross-cutting aspects are the psychological and socio-financial aspects. Patient-reported outcome measures (PROMs) offer insights into concerns and guide interventions, yet long-term QoL studies are limited. Qualitative analysis complements PROMs, offering deeper insights for tailored counseling. Educating patients and caregivers on managing acute side-effects is vital, with early identification of at-risk patients being crucial. Late complications are common and severe, often leaving patients feeling unsupported. Supportive care also plays a crucial role in managing treatment-related side-effects and optimizing recovery from skin care for radiation dermatitis, pain management, pelvic floor physical therapy for sexual dysfunction during and after treatment, use of vaginal dilators during radiation treatment, topical vaginal hormone therapy, and counseling for sexual dysfunction. With the goal of providing increasing integration of services for patients with anal malignancies, patient organizations (such as the Anal Cancer Foundation) have sprung up to offer support, educational initiatives, and resources to improve patient outcomes and QoL.

Indexed as

anal cancerpatient perspectivepatient-reported outcome measuresquality of liferadiotherapythriver

Identifiers

PMID42582940
PMCPMC13459571

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.