ArticleTranslational andrology and urology2026
Stem cell therapy for erectile dysfunction: a systematic review and meta-analysis.
Article in Translational andrology and urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Erectile dysfunction (ED) is a prevalent sexual dysfunction, and due to the limited efficacy of conventional treatments, stem cell (SC)-based regenerative approaches are being extensively investigated. We aimed to investigate the overall effect of SC therapy (SCT) on ED by consolidating findings from clinical studies and offering a general overview of the intervention content and design of these studies. Methods: A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We systematically reviewed MEDLINE, PubMed, Web of Science and ClinicalTrials.gov from inception to July 26, 2024. The outcomes were analyzed using the Comprehensive Meta-Analysis software version 3.0. The Q statistic and I Results: In this meta-analysis, a total of 11 studies evaluated International Index of Erectile Function (IIEF) levels, with an overall mean effect estimated at 16.872 [95% confidence interval (CI): 13.311-20.432]. The findings demonstrated statistically significant improvements in IIEF (Z=9.288, P<0.001), peak systolic velocity (PSV) (Z=5.384, P<0.001), end-diastolic velocity (EDV) (Z=4.604, P<0.001), erection hardness score (EHS) (Z=4.341, P<0.001), and resistive index (RI) (Z=22.302, P<0.001) levels. The pooled analysis demonstrated a significant improvement in IIEF-5 scores, although heterogeneity was extremely high (I Conclusions: This study suggests that SCT may represent a promising alternative approach for the treatment of ED. However, the current evidence is primarily derived from early-phase studies characterized by small sample sizes, heterogeneous populations, lack of control groups, and short follow-up durations. Therefore, while preliminary findings indicate a potential improvement in erectile function following treatment, the overall level of certainty remains low. Further well-designed, randomized controlled trials with larger sample sizes are required before definitive conclusions can be reached and broader clinical implementation can be recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.