ArticleOpen forum infectious diseases2026
Outcomes of a Program to Support Outpatient Antibiotic Adherence Among People Experiencing Housing Instability With Serious Injection Drug-Related Infections in Boston, MA: A Propensity Score Matched Study.
Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Antibiotics are effective for treating serious injection drug-related infections (SIRIs). However, completion rates are often low among people who inject drugs. We evaluated Boston Healthcare for the Homeless Program Infectious Disease Outreach Liaison Team (BOLT), an outpatient liaison program for people experiencing housing instability hospitalized with SIRI, intended to increase intravenous or oral antibiotic completion. Method: We included BOLT enrollees (1 June 2023 to 31 August 2024) and historical controls (1 June 2020 to 28 February 2023). Primary outcomes were the number of re-hospitalizations and emergency department (ED) visits in the 90-day period following the SIRI index hospitalization. The secondary outcome was probability of patient-directed discharge (PDD) from the index hospitalization. BOLT enrollees and historical controls were matched on demographic and clinical characteristics. In regression analyses, we further adjusted for observed characteristics in a doubly robust approach. Results: Prior to matching, BOLT enrollees and historical controls were significantly different on most characteristics, with BOLT enrollees having higher prevalence of osteomyelitis and epidural abscess SIRIs, and opioid and stimulant use disorders. The matched analytic sample included 74 BOLT enrollees and 121 historical controls. The matching approach achieved balance on most characteristics except osteomyelitis prevalence and methadone receipt. In regression analyses, 90-day re-hospitalization was similar between BOLT enrollees and controls ( Conclusions: BOLT was not significantly associated with changes in acute health care utilization. This may reflect unobserved differences between BOLT enrollees and historical controls and suggests a need for additional research to understand program implementation and more proximal health outcomes.
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