Evidence map›Paper›PMID 42582554›Full record

ArticleJournal of the Endocrine Society2026

Dual phenotype in a patient with adult-onset hyperinsulinism and diabetes caused by an activating

Evgenia Globa, Jessica R Hopkinson, Christine S Flaxman, Michaelis Vasiliadis, Sarah J Richardson, Kurt Højlund, Sönke Detlefsen, Sarah E Flanagan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Evgenia GlobaUkrainian Scientific and Practical Center of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kyiv 01021, Ukraine.ORCID https://orcid.org/0000-0001-7885-8195
Jessica R HopkinsonClinical and Biomedical Science, University of Exeter, Exeter EX2 5DW, UK.
Christine S FlaxmanClinical and Biomedical Science, University of Exeter, Exeter EX2 5DW, UK.
Michaelis VasiliadisClinical and Biomedical Science, University of Exeter, Exeter EX2 5DW, UK.
Sarah J RichardsonClinical and Biomedical Science, University of Exeter, Exeter EX2 5DW, UK.ORCID https://orcid.org/0000-0002-1160-6062
Kurt HøjlundSteno Diabetes Center, Odense University Hospital, DK-5000 Odense, Denmark.
Sönke DetlefsenDepartment of Pathology, Odense University Hospital, DK-5000 Odense, Denmark.
Sarah E FlanaganClinical and Biomedical Science, University of Exeter, Exeter EX2 5DW, UK.ORCID https://orcid.org/0000-0002-8670-6340

Funding

Wellcome Trust
6 · The paper itself

Abstract

Context: The coexistence of diabetes and hyperinsulinemic hypoglycemia (HI) within a family is rare. Activating Methods: We studied a family where members were affected by HI (n = 5), diabetes (n = 5), or both conditions (n = 1). Clinical, biochemical, and imaging data were collected. Genetic testing for variants in known monogenic diabetes and HI genes was performed in the proband, followed by cascade testing in available relatives. Pancreatic tissue was examined by immunohistochemistry and immunofluorescence. Results: A heterozygous, p.(Ser64Phe) Conclusion: We describe the fourth family with a pathogenic

Indexed as

diabetesdifficult managementhypoglycemiaoncogenic potentialrecurrent insulinomatosis

Identifiers

PMID42582554
PMCPMC13457921

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.