ArticleJournal of diabetes and metabolic disorders2026
Association of a near-MC4R gene variant (rs17782313) with hyperphagia among patients with severe obesity.
Article in Journal of diabetes and metabolic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Obesity is a multifaceted issue influenced by genetic, environmental, and psychological factors. Genetic predispositions significantly contribute to the risk of obesity in individuals. A deficiency in the melanocortin-4 receptor ( Methods: Genotypes of the near-MC4R variant rs17782313 were compared between patients with severe obesity and hyperphagia (cases) and patients with severe obesity without hyperphagia (controls). Factors such as body mass index (BMI), family history of obesity before puberty, and age at onset of obesity were also assessed. The genotyping of the Results: Analysis of the variant rs17782313 demonstrated a statistically significant positive association with hyperphagia among patients with obesity (ꭓ Conclusion: These findings underscore the importance of genetic factors in understanding hyperphagic behaviors. The
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