ArticleAnnals of surgical treatment and research2026
A preliminary experimental study of venoactive compounds on human lymphatic endothelial cells: cellular response and therapeutic potential.
Article in Annals of surgical treatment and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Lymphedema is a common complication following surgical procedures, particularly in breast cancer patients. However, no effective medical treatment has been clearly established. Venoactive compounds (venoactive drugs, VADs) are frequently used as an alternative option, despite limited supporting evidence. This study aimed to evaluate their potential therapeutic role in lymphedema. Methods: Human lymphatic endothelial cells (HLECs) were used to assess the effects of diosmin, calcium dobesilate, and Results: Treatment with VADs showed an overall tendency to suppress cell migration compared to the control. On the other hand, there was no significant difference in the tube formation. Western blot analysis revealed that Conclusion: VADs did not directly promote lymphangiogenesis in HLECs. Their therapeutic effects in lymphedema may instead be mediated by microvascular stabilization through anti-inflammatory, antioxidant, and permeability-reducing mechanisms. Further experimental and clinical studies are needed to validate these findings.
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