ArticleJournal of biomedical physics & engineering2026
A Comparative Analysis of Virtual 2D VMAT-Based SFRT and 3D Lattice Radiotherapy: Evaluation of Dosimetric and Therapeutic Outcomes.
Article in Journal of biomedical physics & engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Spatially Fractionated Radiotherapy (SFRT) can be implemented using Volumetric-Modulated Arc Therapy (VMAT) in either two-dimensional (2D) or three-dimensional (3D) configurations. Objective: This study aimed to compare the dosimetric and clinical outcomes of two VMAT-based SFRT techniques for large lung tumors. Material and Methods: In this experimental study, SFRT plans were designed for each patient using cylindrical and spherical grid targets. Single-fraction prescription doses of 15 and 20 Gy were delivered to the grid target isocenters using 6 MV Flattening-filter-free (FFF) photon beams. Results: The 2D SFRT plan demonstrated higher Gross Tumor Volume (GTV) mean dose, GTV Equivalent Uniform Dose (EUD), and Valley-to-peak Dose ratio (VPDR) compared to the 3D lattice plan. However, the 3D Lattice Radiotherapy (3D-LRT) technique provided a better therapeutic ratio and more uniform valley-peak dose distribution. Both plans demonstrated therapeutic ratios greater than one with minimal Normal Tissue Complication Probability (NTCP). Conclusion: Both 2D and 3D lattice VMAT-based SFRT techniques effectively delivered high radiation doses with steep dose gradients within the GTV, minimizing normal tissue exposure and reducing the risk of complications.
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