ArticleFrontiers in surgery2026
Case Report: Retrosternal parathyroid lipoadenoma in an obese male patient-diagnostic pitfalls and postoperative biphasic parathyroid hormone dynamics.
Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Parathyroid lipoadenoma is a rare histologic variant of parathyroid adenoma. Its occurrence in the retrosternal mediastinum poses significant diagnostic and surgical challenges. The clinical significance lies not in its rarity, but in the diagnostic pitfalls it presents, particularly when located in the retrosternal mediastinum. We present a case that underscores the pitfalls in preoperative diagnosis and the intricacies of minimally invasive resection. Case presentation: A 36-year-old obese man (BMI 31 kg/m Conclusion: For patients with a mediastinal mass accompanied by hypercalcemia, comprehensive clinical evaluation is required to exclude ectopic primary hyperparathyroidism, rather than interpreting imaging findings in isolation. Subxiphoid VATS is the preferred technique for high retrosternal tumors in patients with challenging anatomical features. Familiarity with postoperative biphasic PTH changes and Hungry Bone Syndrome is essential for accurate interpretation of perioperative biochemical results.
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