ArticleOpen forum infectious diseases2026
Association of Cannabis Use With Risk of Subsequent Falls Among Adults Aging With HIV.
Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
13 authors.
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Abstract
Background: Potential harms of preventable/modifiable use of substances, such as cannabis, among aging people with HIV (PWH) are unclear. We characterized longitudinal associations between current cannabis use and subsequent fall risk among aging PWH. Method: Participants in the Advancing Clinical Therapeutics Globally (ACTG) A5322 study self-reported current cannabis use and any fall(s) annually and semiannually, respectively. Generalized linear models and inverse probability weighting were used to assess associations between cannabis use and subsequent fall risk, adjusting for baseline covariates (age, sex assigned at birth, and race/ethnicity), time-varying confounders, and study attrition. Results: Among 957 participants (median age, 51 years), 18.2% reported current cannabis use at baseline; 18.6% reported falling in the first year of the longitudinal study. Current cannabis use was associated with moderate risk of any falls in the following year in baseline covariate-adjusted analysis (risk ratio [RR], 1.27 95% CI, 1.02, 1.57; Conclusions: Among aging PWH, the association between current cannabis use and fall risk was primarily confounded by cigarette smoking status. Future studies should incorporate more granular cannabis use data on falls risk, including cannabis composition or strain and dose.
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