Evidence map›Paper›PMID 42582255›Full record

ArticleFrontiers in cellular and infection microbiology2026

Single-cell transcriptional changes of artemisinin-sensitive K13

Sean V Connelly, Clark Cunningham, Ian Petrow, Nazrin Rustamzade, Jenna Zuromski, Deborah M Sipolski, Christian P Nixon, Jonathan D Kurtis, Jonathan J Juliano, Jeffrey A Bailey and 1 more

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Sean V ConnellyDivision of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC, United States.
Clark CunninghamDivision of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC, United States.
Ian PetrowDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States.
Nazrin RustamzadeDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States.
Jenna ZuromskiDivision of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC, United States.
Deborah M SipolskiDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States.
Christian P NixonDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States.
Jonathan D KurtisDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States.
Jonathan J JulianoDivision of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC, United States.
Jeffrey A BaileyDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States.
Cliff I OduorDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States.

Funding

Relapsing malaria in Africa: mechanisms for persistence amid falciparum declineR01AI165537 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Rhoel David Ramos Dinglasan, Jonathan J Juliano · 2022 to 2026
$3.6M
Mentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6M
Understanding Emerging artemisinin partner drug resistance in eastern AfricaR01AI189911 · NIAID · UNIVERSITY OF NOTRE DAME · PI JEFFREY A. BAILEY, Michael T Ferdig · 2025 to 2026
$1.4M
Investigating the molecular mechanisms of Plasmodium vivax invasion in Duffy-negative hostsF30AI183592 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Sean Connelly · 2024 to 2026
$130k
NIAID NIH HHS F30 AI183592NIAID NIH HHS K24 AI134990NIAID NIH HHS R01 AI165537NIAID NIH HHS R01 AI189911
6 · The paper itself

Abstract

Artemisinin-based therapies have been central to malaria control, but partial resistance in

Indexed as

AntimalarialsArtemisininsDrug ResistancePlasmodium falciparumErythrocytesGene Expression ProfilingHumansMalaria, FalciparumMutationProtozoan ProteinsSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisTranscription, GeneticAntimalarialsArtemisininsartenimolProtozoan Proteinsartemisinindihydroartemisinindrug resistanceKelch13Plasmodium falciparumsingle-cell RNA-seq (scRNA-seq)transcriptome

Identifiers

PMID42582255
PMCPMC13457298

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.