ArticleFrontiers in aging neuroscience2026
Normative age-related changes in resting-state EEG alpha power and theta/alpha ratio across eyes-open and eyes-closed conditions.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Resting-state electroencephalography (EEG) provides a sensitive measure of large-scale neural dynamics and has been widely used to characterize age-related changes in brain function. However, many prior studies have relied on relatively small samples or single-condition recordings, limiting the generalizability of findings. In this study, we investigated normative age-related trajectories of EEG spectral features across eyes-closed (EC) and eyes-open (EO) conditions in a large cohort of healthy adults. After reproducible preprocessing and artifact rejection, a total of 3,229 resting-state EEG recordings from 608 participants aged 20-70 years were included. EEG data were analyzed across eyes-closed (EC) and eyes-open (EO) conditions, pre- and post-task timepoints, and baseline and follow-up sessions when available. We focused on occipital alpha relative power, global theta/alpha ratio, and occipital alpha peak frequency as spectral markers. Linear mixed-effects models with participant-specific random intercepts were used to account for repeated measurements, and model estimates were reported with standard errors, confidence intervals, test statistics, and false discovery rate-adjusted
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