Functional brain network alterations in a rat model of dental malocclusion.

Qian Lv, Jiali Xu, Yuejiao Zhang, Shuang Chen, Meiqing Wang

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Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Qian LvState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science and the Institutes of Brain Science, Fudan University, Shanghai, China.

Jiali XuDepartment of Oral Anatomy and Physiology, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.

Yuejiao ZhangDepartment of Oral Anatomy and Physiology, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.

Shuang ChenDepartment of Prosthodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.

Meiqing WangDepartment of Oral Anatomy and Physiology, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Malocclusion has been associated with alterations in central nervous system function; however, the effects of persistent abnormal occlusal input on whole-brain functional organization remain poorly understood. This study aimed to investigate functional brain network reorganization associated with unilateral anterior crossbite (UAC) in rats. Methods: Fourteen female rats were used, seven of which were treated with left-sided UAC at 6 weeks old and the other seven served as sham-operation controls. Resting-state functional magnetic resonance imaging data were acquired at 26 weeks old. Regional activity in the proprioceptive pathway was assessed, followed by graph theoretical analysis of whole-brain functional networks. Results: UAC rats exhibited altered regional activity in the right ventral posteromedial thalamus ( Conclusion: Long-term UAC in rats is associated with alterations in whole-brain functional network organization. These findings provide new insights into the central neural responses associated with abnormal occlusal input.

Indexed as

amygdalaanxietybrain networkdental malocclusionfunctional MRIorofacial proprioceptive pathway

Identifiers

PMID42582224

DOI10.3389/fnins.2026.1873417

PMCPMC13457461

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.