Evidence map›Paper›PMID 42582185›Full record

ArticleFrontiers in immunology2026

Impact of germline predisposition genes to hematologic malignancies on transplant outcomes and donor selection.

Zhihui Li, Keyan Yang, Caiyan Zhang, Xianxuan Wang, Lei Wang, Jing Li, Xiaopei Wen, Qian Fei, Jiahong Zhai, Yan Zhou and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhihui Li *Department of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China.
Keyan Yang *Department of Molecular Diagnostic Laboratory, Beijing Gobroad Boren Hospital, Beijing, China.
Caiyan ZhangDepartment of Molecular Diagnostic Laboratory, Beijing Gobroad Boren Hospital, Beijing, China.
Xianxuan WangDepartment of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China.
Lei WangDepartment of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China.
Jing LiDepartment of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China.
Xiaopei WenDepartment of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China.
Qian FeiDepartment of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China.
Jiahong ZhaiDepartment of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China.
Yan ZhouDepartment of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China.
Zongyang MingDepartment of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China.
Yanzhi SongDepartment of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China.
Yongqiang ZhaoDepartment of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China.
Tong WuDepartment of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China.
Qinlong ZhengDepartment of Molecular Diagnostic Laboratory, Beijing Gobroad Boren Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Germline predisposition gene mutations may influence outcomes in patients undergoing hematopoietic stem cell transplantation (HSCT). Methods: This retrospective study of 558 patients undergoing HSCT (allo-HSCT in 557 cases, auto-HSCT in 1 case) evaluated the impact of germline predisposition gene mutations on outcomes. Results: Enrichment of Conclusion: Germline mutations, particularly in IACHI-related genes, influence HSCT outcomes. Pre-transplant genetic screening and opting for unrelated donors for homozygous carriers may optimize transplantation strategies.

Indexed as

Donor SelectionGenetic Predisposition to DiseaseGerm-Line MutationHematologic NeoplasmsHematopoietic Stem Cell TransplantationAdolescentAdultChildChild, PreschoolFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesTransplantation, Homologousdonor selectiongermline mutationshematopoietic stem cell transplantationinborn errors of immunityprognosis

Identifiers

PMID42582185
PMCPMC13457106

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.