ArticleFrontiers in oncology2026
Leptomeningeal carcinomatosis in sinonasal NUT carcinoma: a case report and review of intracranial involvement.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sinonasal NUT carcinoma is a rare and highly aggressive malignancy, frequently diagnosed at advanced stages with poor prognosis. Intracranial spread is uncommon and, to our knowledge, leptomeningeal carcinomatosis has not been previously reported in sinonasal NUT carcinoma. Case description: We describe the clinical, radiological, histopathological, and molecular features of a 32-year-old woman with sinonasal NUT carcinoma who developed leptomeningeal carcinomatosis. The patient presented with a rapidly progressive nasoethmoidal mass with intracranial (dural) invasion. Diagnosis was confirmed by nuclear NUT immunoreactivity and identification of a Conclusions: Sinonasal NUT carcinoma with intracranial and meningeal extension may evolve to leptomeningeal carcinomatosis. Early diagnosis and multimodal treatment, including early surgery, may be crucial to improve prognosis.
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