Comparison of intracerebrospinal fluid methotrexate by Ommaya reservoir versus lumbar puncture in leptomeningeal carcinomatosis with hydrocephalus: a retrospective cohort study.

Kun Hong, Chang Liu, Yu Zhang, Yi Li, Qing Li, Junying He, Hui Bu

Abstract read

In one paragraph

Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Kun HongDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Chang LiuDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Yu ZhangDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Yi LiDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Qing LiDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Junying HeDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Hui BuDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Leptomeningeal carcinomatosis (LC) complicated by hydrocephalus carries a poor prognosis. Intracerebrospinal fluid (intra-CSF) chemotherapy is a main treatment, but the optimal route of administration remains unclear. Methods: This retrospective cohort study included 36 LC patients with hydrocephalus who received intra-CSF methotrexate via Ommaya reservoir (OR, Results: The OR group achieved significantly higher overall response rate (86.7% vs. 47.6%, Conclusion: In LC patients with hydrocephalus, intra-CSF methotrexate via OR does not prolong OS but yields superior symptom relief and intracranial pressure control without increased adverse events. Concurrent targeted therapy is independently linked to favorable long-term survival; extraneural metastasis confers higher mortality risk.

Indexed as

hydrocephalusintracerebrospinal fluid chemotherapyleptomeningeal carcinomatosislumbar punctureOmmaya reservoir

Identifiers

PMID42582073

DOI10.3389/fneur.2026.1848001

PMCPMC13457055

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.