ArticleFrontiers in oncology2026
The application of grayscale quantitative analysis in the differential diagnosis of necrosis between cervical lymph node metastases in nasopharyngeal carcinoma and tuberculous lymphadenitis.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the diagnostic value of ultrasound grayscale difference in differentiating necrotic cervical lymph node metastases from nasopharyngeal carcinoma (NPC) and cervical tuberculous lymphadenitis (CTL), and to provide an objective imaging index for clinical differential diagnosis. Materials and methods: A retrospective study in 2023 enrolled 115 patients with necrotic cervical lymphadenopathy, including 27 with NPC and 88 with CTL. All patients underwent conventional ultrasound, contrast-enhanced ultrasound (CEUS), and ultrasound-guided biopsy. The grayscale difference of necrotic areas was measured by RadiAnt DICOM Viewer. SPSS 25.0 was used for statistical analysis, including univariate and multivariate regression for indicator screening, and receiver operating characteristic (ROC) curves for evaluating diagnostic efficacy. Results: The ultrasound grayscale difference was 48.07 ± 11.73 in the NPC group, significantly higher than 20.33 ± 9.31 in the CTL group ( Conclusion: Ultrasound grayscale difference has high diagnostic value in distinguishing necrotic cervical lymph node metastases of NPC from CTL, and can serve as a reliable quantitative imaging indicator. The multivariate regression model further improves diagnostic accuracy and supports clinical decision-making.
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