Evidence map›Paper›PMID 42581759›Full record

ArticleNucleic acids research2026

Partitioning of parental histones between leading and lagging strands is modulated by DNA polymerase dosage.

Quinn Dickinson, Srinivasu Karri, Odile Djom Kenmogne, Shuang Zhu, Juan Carlos Rivera-Mulia, Zhenqing Ye, Zhiquan Wang, Haiyun Gan, Chuanhe Yu

Abstract read
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In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Quinn DickinsonHormel Institute, University of Minnesota, Austin, MN 55912, United States.
Srinivasu KarriHormel Institute, University of Minnesota, Austin, MN 55912, United States.
Odile Djom KenmogneHealth Sciences Program, University of Minnesota, Rochester, MN 55901, United States.
Shuang ZhuSchool of Life Sciences and Biopharmaceutics, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Juan Carlos Rivera-MuliaDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Medical School, Minneapolis, MN 55455, United States.
Zhenqing YeLillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN 55455,United States.
Zhiquan WangDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, United States.
Haiyun GanCAS Key Laboratory of Quantitative Engineering Biology, Guangdong Provincial Key Laboratory of Synthetic Genomics and Shenzhen Key Laboratory of Synthetic Genomics, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.ORCID 0000-0002-0293-8778
Chuanhe YuHormel Institute, University of Minnesota, Austin, MN 55912, United States.ORCID 0000-0003-1885-7224

Funding

Role of nucleosome dynamics in epigenetic inheritanceR01GM130588 · NIGMS · UNIVERSITY OF MINNESOTA · PI YU, CHUANHE · 2019 to 2023
$1.7M
Mechanisms of Nucleosome Dynamics in Epigenetic InheritanceR35GM161350 · NIGMS · UNIVERSITY OF MINNESOTA · PI Chuanhe Yu · 2026 to 2026
$387k
Hormel Startup FundNIGMS NIH HHS R01 GM130588NIGMS NIH HHS R01GM130588NIGMS NIH HHS R35 GM161350NIGMS NIH HHS R35GM161350
6 · The paper itself

Abstract

Epigenetic inheritance relies on the precise recycling of parental histones during DNA replication. The N-terminal region of Pol1, the catalytic subunit of DNA polymerase α, has previously been implicated in chaperoning parental histone recycling. In this study, we identify a single amino acid mutation in the C-terminal region of Saccharomyces cerevisiae Pol1 (pol1-F1396S) that destabilizes the protein and disrupts the transfer of parental histones to the lagging strand during DNA replication. As a primary consequence, pol1-F1396S cells exhibit decreased chromatin stability. Furthermore, we demonstrate that the cellular abundance-or dosage-of all three DNA polymerases (Pol α, Pol δ, and Pol ε) influences the distribution of parental histones between the leading and lagging strands, revealing a dosage-sensitive mechanism of epigenetic regulation during DNA replication.

Indexed as

DNA Polymerase IDNA ReplicationHistonesSaccharomyces cerevisiae ProteinsChromatinDNA Polymerase IIDNA Polymerase IIIEpigenesis, GeneticMutationSaccharomyces cerevisiaeChromatinDNA Polymerase IDNA Polymerase IIDNA Polymerase IIIHistonesPOL1 protein, S cerevisiaeSaccharomyces cerevisiae Proteins

Identifiers

PMID42581759
PMCPMC13462271

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.