Evidence map›Paper›PMID 42581684›Full record

ArticlePediatric pulmonology2026

Utilization of Des-Gamma-Carboxy-Prothrombin in Estimating Vitamin K Status in People With Cystic Fibrosis: A Single Center Retrospective Review.

Senthilkumar Sankararaman, Terri Schindler, Aravind Thavamani, Catherine Pamer, Alison Marie Rodatt, Kimberly A McBennett, Erica Roesch, Alex H Gifford

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Article in Pediatric pulmonology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Senthilkumar SankararamanDivision of Pediatric Gastroenterology, Cleveland Clinic Children's Hospital, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0003-3094-9703
Terri SchindlerDivision of Pediatric Pulmonology, UH Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Aravind ThavamaniDivision of Pediatric Gastroenterology, UH Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-4966-5113
Catherine PamerDivision of Pediatric Pulmonology, UH Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.ORCID https://orcid.org/0009-0009-6983-9545
Alison Marie RodattDivision of Pediatric Pulmonology, UH Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.
Kimberly A McBennettDivision of Pediatric Pulmonology, UH Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0001-9642-3814
Erica RoeschDivision of Pediatric Pulmonology, UH Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Alex H GiffordDivision of Pulmonary, Critical Care, and Sleep Medicine, UH Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-6404-3793

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeople with cystic fibrosis (CF) are at increased risk of fat-soluble vitamin (A, D, E, and K) deficiencies secondary to exocrine pancreatic insufficiency (EPI). Estimation of vitamin K deficiency in routine clinical practice is challenging, and no uniform consensus exists due to lack of an accurate clinical test for the evaluation of its status. We aimed to estimate vitamin K status in people with CF using des-gamma-carboxy-prothrombin (DCP). METHODOLOGY: A single-center retrospective chart review was done between 2022 and 2024. Ninety-four (39 pediatric and 55 adult) people with CF were included for final review.

resultsThe median DCP value was 0.35 ng/mL (IQR 0.2-0.60; range was 0.1-11 ng/mL). Post hoc, we classified patients into low-DCP (0-90th percentile values in DCP or ≤ 2 ng/mL) and high-DCP (91-100th percentile in DCP or >2 ng/mL) groups. Eleven out of 94 (11.7%) patients had DCP > 2 ng/mL; three out of 11 (27%) had advanced CF liver disease (aCFLD), p = 0.011, and another three had other fat-soluble vitamin deficiencies, and low adherence to pancreatic enzymes and/or vitamin supplementation was suspected, p = 0.011. There were no significant differences in demographics (age, gender) or other comorbidities between the groups.

conclusionDCP can be used for estimating vitamin K status, and the prevalence of suboptimal vitamin K status was 11.7%. DCP levels were higher in aCFLD, as well as those with suspected low adherence to pancreatic enzymes and/or vitamin supplementation. Prospective, multicenter clinical trials are needed to evaluate this further.

Indexed as

Cystic FibrosisProtein PrecursorsProthrombinVitamin KVitamin K DeficiencyAdolescentAdultBiomarkersChildChild, PreschoolExocrine Pancreatic InsufficiencyFemaleHumansInfantMaleRetrospective StudiesacarboxyprothrombinBiomarkersProtein PrecursorsProthrombinVitamin KCFcystic fibrosisDCPdes‐gamma‐carboxy‐prothrombinphylloquinonePIVKA‐IIvitamin K

Identifiers

PMID42581684
PMCPMC13462822

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.