Evidence map›Paper›PMID 42581656›Full record

ArticleDevelopment (Cambridge, England)2026

Regulation of lambdoid suture morphogenesis by PDGFRα-dependent chondrocyte programs.

Garrett Bartoletti, Ryan Ebright, Haoyang Liang, Josue Jaramillo, Mimi Sammarco, Xiaojiang Xu, Fenglei He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Garrett BartolettiDepartment of Cell and Molecular Biology, School of Science and Engineering, Tulane University, New Orleans, LA 70118, USA.
Ryan EbrightDepartment of Cell and Molecular Biology, School of Science and Engineering, Tulane University, New Orleans, LA 70118, USA.
Haoyang LiangDepartment of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0009-0003-5246-8406
Josue JaramilloDepartment of Surgery, Tulane School of Medicine, New Orleans, LA 70112, USA.
Mimi SammarcoDepartment of Surgery, Tulane School of Medicine, New Orleans, LA 70112, USA.
Xiaojiang XuDepartment of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Fenglei HeDepartment of Cell and Molecular Biology, School of Science and Engineering, Tulane University, New Orleans, LA 70118, USA.ORCID 0000-0003-4717-8001

Funding

Sex-Based Precision Medicine Research CoreP20GM152305 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Franck Mauvais-Jarvis · 2024 to 2026
$8.9M
Pilot Projects ProgramP30GM145498 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Victoria Perepelitsa Belancio · 2022 to 2026
$8.6M
Molecular mechanisms of tissue interactions during coronal suture developmentR01DE028918 · NIDCR · TULANE UNIVERSITY OF LOUISIANA · PI HE, FENGLEI · 2019 to 2023
$1.8M
Eye, Ear, Nose and Throat Foundation EE240302Eye, Ear, Nose and Throat Foundation, New Orleans EE240302NIDCR NIH HHS DE028918NIDCR NIH HHS R01 DE028918NIGMS NIH HHS P20 GM152305NIGMS NIH HHS P30 GM145498NIGMS NIH HHS P30GM145498NIH HHS
6 · The paper itself

Abstract

Craniosynostosis is a congenital disorder characterized by premature fusion of cranial sutures. Lambdoid synostosis is a rare and severe form of the disease, but its developmental etiology remains poorly understood. Although ectopic cartilage has been associated with lambdoid suture fusion, whether abnormal chondrocyte development is causative has not been directly tested. Here, we have investigated the role of platelet-derived growth factor receptor alpha (PDGFRα) signaling in chondrocyte development and lambdoid suture morphogenesis. Mesoderm-specific expression of an autoactivated Pdgfra allele (Pdgfra+/K) caused premature fusion of the lambdoid and occipitointerparietal sutures, preceded by excessive cartilage expansion during embryogenesis. Spatial transcriptomic analysis identified a PDGFRα-dependent transcriptional program characterized by increased Col2a1, Sox9 and Sfrp2 expression, indicating maintenance of chondrocytes in a proliferative progenitor state. Consistent with this, PDGFRα-activated chondrocytes exhibited increased proliferation. Moreover, expression of Pdgfra+/K in the Col2a1Cre lineage selectively induced occipitointerparietal suture fusion. Together, these findings demonstrate that PDGFRα signaling promotes proliferative cartilage and impairs chondrocyte maturation, identifying dysregulated chondrogenesis as a developmental mechanism underlying lambdoid craniosynostosis.

Indexed as

ChondrocytesCranial SuturesCraniosynostosesMorphogenesisReceptor, Platelet-Derived Growth Factor alphaAnimalsCartilageCell ProliferationChondrogenesisCollagen Type IIGene Expression Regulation, DevelopmentalMesodermMiceSignal TransductionSOX9 Transcription FactorCollagen Type IIReceptor, Platelet-Derived Growth Factor alphaSOX9 Transcription FactorChondrocyteCraniosynostosisEndochondral ossificationLambdoid sutureMesodermPdgfra

Identifiers

PMID42581656
PMCPMC13690066

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.