Evidence map›Paper›PMID 42581647›Full record

ArticleBrain and behavior2026

Emerging Trends and Hot Spots in Tauopathy Research (2003-2025): A Bibliometric Analysis.

Si-Yao Zhang, Hui-Jie Ren, Hao-Yu Liu, Shu-Ying Xu, Yong-Jun Peng

Erratum issuedAbstract read
In one paragraph

Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Si-Yao ZhangDepartment of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.ORCID https://orcid.org/0009-0007-6941-6230
Hui-Jie RenDepartment of Traditional Chinese Medicine, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu Province, China.
Hao-Yu LiuDepartment of Acupuncture-Moxibustion, Tuina and Rehabilitation, Kunshan Affiliated Hospital of Nanjing University of Chinese Medicine, Kunshan, Jiangsu Province, China.
Shu-Ying XuDepartment of Acupuncture-Moxibustion, Tuina and Rehabilitation, Kunshan Affiliated Hospital of Nanjing University of Chinese Medicine, Kunshan, Jiangsu Province, China.
Yong-Jun PengDepartment of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to systematically analyze the developmental trajectory, research landscape, and thematic evolution of tauopathy research from 2003 to 2025 using bibliometric methods.

methodsA total of 6752 publications retrieved from the Web of Science Core Collection (WoSCC) were analyzed using the R package bibliometrix and VOSviewer to construct bibliometric networks, including co-authorship, co-citation, and keyword co-occurrence analyses. Scimago Graphica was used to visualize international collaboration patterns.

resultsThe annual number of publications on tauopathy increased markedly during the period 2003-2025, reflecting sustained global research interest. The United States was the leading contributor in both publication output and citation impact, while the University of Pennsylvania emerged as a key institution. Among individual researchers, the most productive authors and influential scholars were identified through publication output and citation-based metrics. Citation analysis highlighted the enduring impact of highly cited studies, particularly those establishing key biomarker frameworks for Alzheimer's disease research.Keyword-based analysis further revealed a shift from traditional mechanistic studies toward more integrative research themes, such as tau-amyloid-β interactions, neurodegeneration, and glial involvement, alongside continued interest in tau-targeted therapeutic strategies.

conclusionThis bibliometric analysis provides a quantitative and structured overview of the global tauopathy research landscape. Beyond confirming established patterns, it captures the dynamic evolution of research priorities and identifies emerging directions, offering a data-driven basis for future investigations.

Indexed as

BibliometricsBiomedical ResearchTauopathiesHumansAlzheimer's diseasebibliometricsemerging trendshotspotstauopathy

Identifiers

PMID42581647
PMCPMC13462673

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.